{"id":10321,"date":"2016-10-24T10:26:00","date_gmt":"2016-10-24T10:26:00","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=10321"},"modified":"2016-10-24T10:26:00","modified_gmt":"2016-10-24T10:26:00","slug":"madison-startup-advances-three-in-one-cancer-drug-rooted-at-uw","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/madison-startup-advances-three-in-one-cancer-drug-rooted-at-uw\/","title":{"rendered":"Madison startup advances three-in-one cancer drug rooted at UW"},"content":{"rendered":"

\n

\"Vials<\/a>
Vials containing freeze-dried samples of Triolimus, a drug being developed by Co-D Therapeutics.<\/figcaption><\/figure>\n

Co-D Therapeutics<\/a>, a University of Wisconsin\u2013Madison spinoff, is developing a three-drug cocktail to battle a wide range of cancers. The first target for Co-D is angiosarcoma, a rare and lethal cancer that arises from blood vessels.<\/span><\/p>\n

The company\u2019s submicroscopic package contains paclitaxel, a standard cancer drug, combined with two other drugs designed to reduce the resistance that often develops against chemotherapy drugs.<\/span><\/p>\n

The triple-threat product was invented by two of Co-D\u2019s co-founders, chief scientific officer\u00a0Glen Kwon<\/span><\/a>, a professor of pharmaceutical science at UW\u2013Madison, and chief medical officer Kevin Kozak, a radiation oncologist now at Mercy Health System in Janesville.<\/span><\/p>\n

Kwon has been working on new drug carriers and combination cancer treatments for more than 20 years; Kozak is an expert on angioscarcoma.<\/span><\/p>\n

Four patents on the candidate drug, called Triolimus, have been issued to the\u00a0Wisconsin Alumni Research Foundation<\/span><\/a>\u00a0(WARF).<\/span><\/p>\n

[pullquote]Chemotherapy drugs typically kill fast-dividing cells, and in recent years, they are combined with newer agents intended to moderate cancer\u2019s resistance.[\/pullquote]<\/p>\n

The Triolimus package is a double-layer structure called a micelle that is only 40 nanometers in diameter \u2014 about 1\/200 the diameter of a human hair. Each individual component of Triolimus has been tested in humans and several have Food and Drug Administration approval.<\/span><\/p>\n

Although paclitaxel and related cancer drugs derived from the Pacific yew tree are in widespread use, they usually require a toxic solvent that can cause dangerous anaphylactic shock in patients. The micelle technology eliminates the solvent and allows the simultaneous administration of other insoluble drugs.<\/span><\/p>\n

If the product works against angiosarcoma, it could be used against breast, lung and other common cancers that are now treated with paclitaxel.<\/span><\/p>\n

Chemotherapy drugs typically kill fast-dividing cells, and in recent years, they are combined with newer agents intended to moderate cancer\u2019s resistance.<\/span><\/p>\n

\n

\"Kwon\"<\/a>
Kwon<\/figcaption><\/figure>\n

The selection of agents in Triolimus followed this newer approach:<\/span><\/p>\n

– The chemotherapy, paclitaxel, is a taxol drug that interferes with cell division and attacks fast-dividing cancer cells. The near-insolubility of taxol drugs in water has caused troublesome side effects and limited doses.<\/span><\/p>\n

– Rapamycin interferes with a signaling pathway that many cancers use to evade chemotherapy agents.<\/span><\/p>\n

– 17-AAG is a candidate drug that inhibits drug resistance through a different mechanism.<\/span><\/p>\n

The result is a single, apparently safe package that can carry multiple drugs and, by eliminating the toxic solvents, allows for increased dosages.<\/span><\/p>\n

The carrier technology is key to these benefits, Kwon says. \u201cThe micelle can safely deliver a really potent three-drug combination, even though all of them are insoluble in water.\u201d<\/span><\/p>\n

\n

\"Kozak<\/a>
Kozak<\/figcaption><\/figure>\n

To make the package containing its three-drug payload, \u201cyou simply mix the drugs with a solvent and water, remove the solvent under reduced pressure, and the micelles self-assemble,\u201d says Kwon. \u201cYou freeze-dry the product and when it\u2019s time to use it, you reconstitute it with water.\u201d<\/span><\/p>\n

Kozak did research on angiosarcoma at the UW\u2013Madison\u00a0School of Medicine and Public Health<\/span><\/a>. \u201cI did postdoctoral research on blood vessel abnormalities in common cancers,\u201d he says. \u201cThis combined focus on blood vessels and cancer naturally led me to angiosarcoma.\u201d<\/span><\/p>\n

In 2015, Co-D received FDA orphan drug designation for Triolimus, which will entitle the company to seven years of market exclusivity for treating angiosarcoma with it. Additional benefits include tax credits related to clinical trial expenses, potential exemption from the FDA user fee, and smaller trials than those required for standard new drug applications.<\/span><\/p>\n

Research in an animal model of angioscarcoma showed a better outcome from the triple-drug Triolimus than for a micelle carrying paclitaxel alone. In both cases, the micelle permitted a paclitaxel dose three times above the standard dose.<\/span><\/p>\n

\n

\"Saad\"<\/a>
Saad<\/figcaption><\/figure>\n

Co-D is raising funds to complete preclinical studies and a phase I clinical trial with angiosarcoma patients. \u201cWe have a clear path to approval,\u201d says Abdalla Saad, company president and CEO. \u201cBecause of the rarity of angiosarcoma and the need of a more effective and safer treatment, we anticipate approval after phase II clinical trials.\u201d<\/span><\/p>\n

Saad, who has a master\u2019s in biotechnology from UW\u2013Madison, says, \u201cOur research and development costs are low compared to costs for new chemical entities. The manufacturing method developed on campus will be transferred to a contract manufacturer for scale-up.\u201d<\/span><\/p>\n

\u201cThere is no question that Triolimus will be effective, as it contains the most widely used anti-cancer agent in the history of man,\u201d says Kozak. \u201cMy expectation, based on the biochemistry and our preliminary data, is that it will significantly exceed the activity of paclitaxel. But even if it does not, the formulation reduces the need to give patients a toxic solvent, and that alone is a potential benefit.\u201d<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

The company\u2019s submicroscopic package contains paclitaxel, a standard cancer drug, combined with two other drugs designed to reduce the resistance that often develops against chemotherapy drugs.<\/p>\n

The triple-threat product was invented by two of Co-D\u2019s co-founders, chief scientific officer Glen Kwon, a professor of pharmaceutical science at UW\u2013Madison, and chief medical officer Kevin Kozak, a radiation oncologist now at Mercy Health System in Janesville.<\/p>\n","protected":false},"author":6,"featured_media":10322,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26,17],"tags":[],"class_list":["post-10321","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333-300x199.jpg",300,199,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",95,63,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",500,333,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",96,64,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/10\/Co-D-therapeutic-Tony-Tam_0006-500x333.jpg",150,100,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Medicine<\/a> Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/10321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=10321"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/10321\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/10322"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=10321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=10321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=10321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}