{"id":11033,"date":"2016-12-26T07:32:08","date_gmt":"2016-12-26T07:32:08","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=11033"},"modified":"2016-12-26T07:32:08","modified_gmt":"2016-12-26T07:32:08","slug":"gene-test-pinpoint-patients-sensitive-new-type-cancer-drug","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/gene-test-pinpoint-patients-sensitive-new-type-cancer-drug\/","title":{"rendered":"Gene Test Could Pinpoint Patients Sensitive to New Type of Cancer Drug"},"content":{"rendered":"
\"\"
Photo: Jan Chlebik for the ICR)<\/figcaption><\/figure>\n

Testing for a gene commonly mutated in ovarian cancers could pick out patients who will respond well to a promising new class of cancer drugs, a major new study reveals.<\/span><\/p>\n

Scientists found that defects in a gene called ARID1A caused sensitivity to new drugs targeting the DNA repair process within tumour cells.<\/span><\/p>\n

The new drugs \u2013 called ATR inhibitors \u2013 are already being tested in early clinical trials, and the new research could help identify those patients who will benefit most.<\/span><\/p>\n

Scientists at The Institute of Cancer Research, London used molecular screening techniques to find that cancers with mutations in ARID1A were particularly sensitive to ATR inhibitors.<\/span><\/p>\n

Targeting the tumours<\/strong><\/span><\/p>\n

ARID1A is mutated in a wide range of hard-to-treat tumour types, including ovarian cancer and stomach cancer, but until now there has been no way of targeting treatment at tumours with this genetic defect.<\/span><\/p>\n

The research, which is\u00a0published in the journal\u00a0Nature Communications<\/em><\/a>, was funded by\u00a0Cancer Research UK<\/a>\u00a0and\u00a0Breast Cancer Now<\/a>.<\/span><\/p>\n

Scientists at the ICR found that ATR inhibitors stopped cancer cells with ARID1A mutations from growing, both in culture dishes and in mice.<\/span><\/p>\n

They also found that switching off the ARID1A gene in breast and bowel cancer cells greatly increased their sensitivity to ATR inhibitors.<\/span><\/p>\n

‘Synthetic lethality’<\/strong><\/span><\/p>\n

The researchers found the treatment killed cancer cells with ARID1A mutations through a process called \u2018synthetic lethality\u2019.<\/span><\/p>\n

Cancer cells with ARID1A mutations become particularly reliant on the DNA safeguarding activity of the ATR protein to survive \u2013 so they are especially sensitive to drugs that block its effects.<\/span><\/p>\n

Patients on clinical trials of ATR inhibitors could now start to be tested for ARID1A mutations in their tumours \u2013 in order to assess whether those with the genetic defects are particularly likely to benefit.<\/span><\/p>\n

Dr Chris Lord<\/a>, Leader of the\u00a0Gene Function Team<\/a>\u00a0at the ICR, said: \u201cOur research has opened up a potential way of personalising treatment for cancer by targeting drugs to those patients who will benefit most.<\/span><\/p>\n

\u201cWe found in cell cultures and in mice that cancers with defective versions of the ARID1A gene are particularly sensitive to a new class of drug called ATR inhibitors.\u201d<\/span><\/p>\n

\u201cOur research could lead to patients with ARID1A mutant tumours being assessed for whether they respond particularly well to this new class of cancer treatment.\u201d<\/span><\/p>\n

Step closer to personalised medicine<\/strong><\/span><\/p>\n

Dr Justine Alford, Cancer Research UK\u2019s Senior Science Information Officer, said: \u201cBy identifying a potential way to exploit a specific genetic vulnerability in cancer this research could point the way to tailoring treatments to each patient, helping to make them kinder and more effective. The next steps will be to better understand the effects of targeting this weakness, and to find out whether this promising strategy will work in people.\u201d<\/span><\/p>\n

Katie Goates, Senior Research Communications Officer at Breast Cancer Now, said:\u00a0<\/strong>\u201cThis early finding could bring us a step closer to more \u2018personalised\u2019 medicine, targeting treatment to exploit weaknesses in patients\u2019 tumours and hopefully improve their chances of survival.<\/span><\/p>\n

\u201cIt\u2019s particularly exciting to see an idea that was initially tested in breast cancer cells be translated into potential benefit for a number of other cancers. We hope these findings now lay the groundwork for clinical trials to investigate the potential of ATR inhibitors as a targeted cancer treatment in the near future.\u201d<\/span><\/p>\n

\n

Source: dddmag.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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