{"id":11179,"date":"2017-01-15T07:08:04","date_gmt":"2017-01-15T07:08:04","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=11179"},"modified":"2017-01-15T07:08:04","modified_gmt":"2017-01-15T07:08:04","slug":"scientists-uncover-new-way-defeat-therapy-resistant-prostate-cancer","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/scientists-uncover-new-way-defeat-therapy-resistant-prostate-cancer\/","title":{"rendered":"Scientists Uncover New Way to Defeat Therapy-Resistant Prostate Cancer"},"content":{"rendered":"

\"\"A new study led by scientists from the Florida campus of The Scripps Research Institute (TSRI) sheds light on a signaling circuit in cells that drives therapy resistance in prostate cancer. The researchers found that targeting the components of this circuit suppresses advanced prostate cancer development.<\/span><\/p>\n

The study, led by TSRI Associate Professor Jun-Li Luo, was published online ahead of print in the journal\u00a0Molecular Cell<\/em>.<\/span><\/p>\n

A New Strategy to Fight Prostate Cancer<\/strong><\/span><\/p>\n

Prostate cancer\u2014which, according to the American Cancer Society, affects one in six American men\u2014is the second-leading cause of death after lung cancer in American men.<\/span><\/p>\n

Currently, the most effective treatment for advanced prostate cancer is to deprive the cancer of what feeds it\u2014androgen hormones, such as testosterone. Unfortunately, almost all patients eventually develop resistance to this therapy, leaving doctors with no options to counteract the inevitable. \u00a0 \u00a0<\/span><\/p>\n

The new study shows that a \u201cconstitutively active\u201d signaling circuit can trigger cells to grow into tumors and drive therapy resistance in advanced prostate cancer. A cell signal pathway with constitutive activity requires no binding partner (ligand) to activate; instead, the signaling circuit continually activates itself.<\/span><\/p>\n

This signaling circuit, which is composed of the protein complex I\u03baB\u03b1\/NF-\u03baB (p65) and several other molecules, controls the expression of stem cell transcription factors (proteins that guide the conversion of genetic information from DNA to RNA) that fuel the aggressive growth of these resistant cancer cells.<\/span><\/p>\n

\u201cThe fact that the constitutive activation of NF-kB in the circuit is independent of traditional activation opens the door for potential treatment options,\u201d said Luo.<\/span><\/p>\n

Targeting Other Signaling Components Shows Promise<\/strong><\/span><\/p>\n

NF-kB plays important roles in cancer development, and it is regarded as one of the most important targets for cancer therapy. However, the use of NF-kB inhibitors in treating cancer is complicated by severe side effects related to immunosuppression caused by indiscriminate inhibition of NF-kB in normal immune cells.<\/span><\/p>\n

Luo noted that targeting the other\u00a0non<\/em>-I\u03baB\u03b1\/NF-\u03baB components in this signaling circuit would avoid the suppression of NF-\u03baB in normal immune cells while keeping the potent anti-cancer efficacy.<\/span><\/p>\n

In addition to I\u03baB\u03b1\/NF-\u03baB, the signaling circuit includes the microRNA miR-196b-3p, Meis2 and PPP3CC. While miR-196b-3p promotes tumor development, Meis2, which is an essential developmental gene in mammals, can disrupt the circuit when overexpressed. The protein PPP3CC can inhibit NF-\u03baB activity in prostate cancer cells.<\/span><\/p>\n

\u201cDisrupting this circuit by targeting any of its individual components blocks the expression of these transcription factors and significantly impairs therapy-resistant prostate cancer,\u201d said TSRI Research Associate Ji-Hak Jeong, the first author of the study.<\/span><\/p>\n

Source: dddmag.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A new study led by scientists from the Florida campus of The Scripps Research Institute (TSRI) sheds light on a signaling circuit in cells that drives therapy resistance in prostate cancer. The researchers found that targeting the components of this circuit suppresses advanced prostate cancer development. The study, led by TSRI Associate Professor Jun-Li Luo, […]<\/p>\n","protected":false},"author":6,"featured_media":11180,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16,17],"tags":[],"class_list":["post-11179","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biology","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",800,796,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer-300x300.jpg",300,300,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer-768x764.jpg",750,746,true],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",750,746,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",800,796,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",800,796,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",800,796,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",573,570,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",600,597,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",600,597,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",492,490,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",362,360,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",65,65,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",640,637,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",96,96,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/01\/ddd1608_prostate_cancer.jpg",150,149,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Biology<\/a> Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/11179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=11179"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/11179\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/11180"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=11179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=11179"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=11179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}