{"id":12839,"date":"2017-08-08T10:01:53","date_gmt":"2017-08-08T10:01:53","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=12839"},"modified":"2017-08-08T10:01:53","modified_gmt":"2017-08-08T10:01:53","slug":"pregnancy-loss-evolution-sex-linked-cellular-line-dance","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/pregnancy-loss-evolution-sex-linked-cellular-line-dance\/","title":{"rendered":"Pregnancy loss and evolution of sex linked by cellular line dance"},"content":{"rendered":"
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Dan Levitis<\/figcaption><\/figure>\n

After<\/span>\u00a0Dan Levitis<\/a>\u00a0and his wife lost two pregnancies, before having their three children, he was drawn to investigate why pregnancy loss is so common, and whether other living beings face the same struggle his family did.<\/span><\/p>\n

Levitis, a scientist in the University of Wisconsin\u2013Madison Department of Botany, had one main suspect in mind: meiosis, which organisms use to produce sperm and eggs for sexual reproduction. He describes meiosis as an intricate cellular line dance, one that mixes up chromosomes to reshuffle genes. This rearrangement helps create offspring that are different from their parents, offspring that might be better equipped to survive in a changing world.<\/span><\/p>\n

But meiosis is also one of the most complex processes that cells undergo, and a lot can go wrong as chromosomes tangle and untangle themselves. Levitis figured that this complexity might lead to problems creating healthy progeny.<\/span><\/p>\n

In new research published this week (Aug. 1, 2017) in the<\/span>\u00a0Proceedings of the Royal Society B<\/a>, Levitis and his collaborators report that meiosis takes a heavy toll on the viability of offspring \u2014 and not just for humans. Creatures from geckos to garlic and cactuses to cockroaches pay a price to undergo sexual reproduction.<\/span><\/p>\n

The work provides deeper context on the fundamental biological causes behind pregnancy loss, and suggests that the advantages of sexual reproduction must overcome the severe constraints imposed by meiosis.<\/span><\/p>\n

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Anne Pringle<\/figcaption><\/figure>\n

\u201cIt\u2019s known that for humans, the primary cause of pregnancy loss is chromosomal abnormalities arising from meiosis,\u201d says<\/span>\u00a0Anne Pringle<\/a>, a professor of botany at UW\u2013Madison and another author of the research. \u201cBut what wasn\u2019t at all clear was whether meiosis is a leading cause of inviability not just in humans, but wherever it occurs.\u201d<\/span><\/p>\n

To answer this question, Levitis compared the viability of offspring produced by three different kinds of reproduction. Sexual reproduction, where two players make a genetic contribution, always requires meiosis. On the other hand, asexual reproduction \u2014 where the offspring are clones of their parents \u2014 usually uses the much simpler mitosis, a comparatively easy cloning of cells, no genetic reshuffling required. When asexual reproduction does use meiosis, it is even more complicated than sex.<\/span><\/p>\n

In this three-way comparison, Levitis found that more complex reproduction resulted in lower offspring survival. For example, asexual lizards that use meiosis had lower viability than sexual lizards that also use meiosis because asexual meiosis was more complicated. Yet the organisms that used the simpler mitosis, like palm trees and damselflies, produced healthier offspring.<\/span><\/p>\n

This pattern held true in 42 of 44 species. \u201cWhen you get a result that consistent across such a wide range of organisms, it\u2019s suspicious,\u201d says Levitis. But even after a second look, the data checked out. Something about meiosis, seemingly its complexity, kills offspring.<\/span><\/p>\n

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Asexual lizards that use meiosis had lower viability than sexual lizards that also use meiosis because asexual meiosis was more complicated. Yet the organisms that used the simpler mitosis, such as palm trees and damselflies, produced healthier offspring. This pattern held true in 42 of the 44 species studied. PHOTOS: ARNOLD SCIBERRAS, SERGE MELKI\/WIKIMEDIA COMMONS<\/figcaption><\/figure>\n

\u201cIf you\u2019re making your tally sheet, all the pluses and minuses of sex, the fact that sex requires this deadly process is pretty clearly a disadvantage,\u201d says Levitis.<\/span><\/p>\n

Regarding the evolution of sex, Levitis\u2019 findings suggest that the advantages of going through meiosis must be significant enough to balance that tally sheet. The reshuffling of genes between two parents during sex might provide even more of an advantage than previously thought.<\/span><\/p>\n

The other takeaway, says Levitis, is that although it\u2019s easy to think that natural selection can solve every problem \u2014 and that we might wish it had, such as for high rates of pregnancy loss \u2014 sometimes it comes up against fundamental constraints. Meiosis seems to be one of those insurmountable barriers.<\/span><\/p>\n

Yet the tradeoff, offspring that are truly unique with novel genetic combinations to face a challenging world, must be worth it.<\/span><\/p>\n