{"id":14012,"date":"2017-12-26T08:01:47","date_gmt":"2017-12-26T08:01:47","guid":{"rendered":"https:\/\/www.revoscience.com\/en\/?p=14012"},"modified":"2020-05-27T06:19:05","modified_gmt":"2020-05-27T06:19:05","slug":"kiss-death-prostate-cancer","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/kiss-death-prostate-cancer\/","title":{"rendered":"A kiss of death for prostate cancer"},"content":{"rendered":"<p><span style=\"color: #000000\"><em><strong>Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer.<\/strong><\/em><\/span><\/p>\n<p><span style=\"color: #000000\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-14013\" src=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png\" alt=\"\" width=\"387\" height=\"194\" title=\"\" srcset=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png 387w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock-300x150.png 300w\" sizes=\"auto, (max-width: 387px) 100vw, 387px\" \/>The drug Gefitinib is used to treat breast, lung, and other cancers by inhibiting epidermal growth factor receptor (EGFR) signaling, but it has only a limited effect on prostate cancer. EGFR, present on the cell membrane, is involved in cell proliferation and the development of dermis, lung, and digestive tissues. When a mutation causes its over-activation, it can lead to increased cell proliferation and tumor formation.<\/span><\/p>\n<p><span style=\"color: #000000\">Tadashi Matsuda of Hokkaido University and his colleagues in Japan investigated human prostate cancer cells to determine if there is an unknown up-regulation mechanism in the EGFR pathway.<\/span><\/p>\n<p><span style=\"color: #000000\">When EGFR is attached to a small protein called ubiquitin, it is given \u201cthe kiss of death\u201d and tagged for degradation inside the cell. This tagging process is facilitated by a protein called c-CBL. The degradation of EGFR leads to less signaling from the receptor and reduced cell proliferation.\u00a0<\/span><\/p>\n<p><span style=\"color: #000000\">Matsuda and his team found that signal-transducing adaptor protein-2 (STAP-2) stabilizes EGFR by inhibiting its c-CBL-mediated ubiquitination. Furthermore, when the team suppressed STAP-2, the prostate cancer cells showed reduced proliferation and did not form a tumor when transplanted into mice.\u00a0<\/span><\/p>\n<p><span style=\"color: #000000\">\u201cSTAP-2 inhibitors could play a role in treating Gefitinib-resistant prostate cancers. Further studies on STAP-2 will provide new insights into cancer physiology and support the development of anticancer therapies,\u201d says Tadashi Matsuda. The study was published in the Journal of Biological Chemistry.<\/span> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer. The drug Gefitinib is used to treat breast, lung, and other cancers by inhibiting epidermal growth factor receptor (EGFR) signaling, but it has only a limited effect on prostate cancer. EGFR, present [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":14013,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16,26,17],"tags":[],"class_list":["post-14012","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biology","category-medicine","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock-150x150.png",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock-300x150.png",300,150,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",95,48,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",387,194,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",96,48,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2017\/12\/topslide-cancer-cell-shutterstock.png",150,75,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"<a href=\"https:\/\/www.revoscience.com\/en\/category\/news\/biology\/\" rel=\"category tag\">Biology<\/a> <a href=\"https:\/\/www.revoscience.com\/en\/category\/health\/medicine\/\" rel=\"category tag\">Medicine<\/a> <a href=\"https:\/\/www.revoscience.com\/en\/category\/news\/research\/\" rel=\"category tag\">Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/14012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=14012"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/14012\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/14013"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=14012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=14012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=14012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}