{"id":14627,"date":"2018-03-05T08:28:10","date_gmt":"2018-03-05T08:28:10","guid":{"rendered":"https:\/\/www.revoscience.com\/en\/?p=14627"},"modified":"2020-05-27T06:06:54","modified_gmt":"2020-05-27T06:06:54","slug":"viruss-path-body-depends-infection-site","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/viruss-path-body-depends-infection-site\/","title":{"rendered":"Virus\u2019s Path through the Body Depends on Infection Site"},"content":{"rendered":"

\"\"A person is more likely to get infected by HIV through anal intercourse than vaginal, but no one knows quite why. A new study by scientists at the Gladstone Institutes shows that infection sites could affect the immune system\u2019s response to a virus and the way the virus spreads through the body.<\/span><\/p>\n

The study, published in\u00a0Mucosal Immunology<\/em>, aimed to understand how the immune system responds to a virus when it enters the body through different points. The researchers focused particularly on common routes of sexual transmission of viruses, such as the lower female reproductive tract and the lower gastrointestinal tract that includes the large intestine and the anus.<\/span><\/p>\n

These mucosal barriers\u2014the body\u2019s openings lined with a membrane called mucosa\u2014are responsible for distinguishing between harmless bacteria that normally reside in us and potentially dangerous pathogens, as well as other substances, such as food or sperm.<\/span><\/p>\n

\u201cOur body is constantly trying to balance between tolerating harmless elements and defending us against possible threats,\u201d said Shomyseh Sanjabi, PhD, assistant investigator at Gladstone who led the study. \u201cWe wanted to learn whether the mechanisms that allow the body to be tolerant would affect its ability to elicit a protective immune response when needed. And, whether the process was different depending on the virus\u2019s point of entry.\u201d<\/span><\/p>\n

Sanjabi\u2019s team discovered that, in fact, the body\u2019s reaction is different based on the infection site. They showed that the vaginal and rectal cavities activate a distinct immune response to the same pathogen.<\/span><\/p>\n

To conduct the study, Sanjabi and her team created a new model of viral infection through the rectum that uses lymphocytic choriomeningitis virus (LCMV), a rodent virus often used in research to model other pathogens. They then compared their findings to their previous work on vaginal infection by LCMV.<\/span><\/p>\n

In 2016, they showed that vaginal infection causes a delayed response by protective cells. As a result, the immune system takes longer to clear the virus from the female reproductive tract. They also noticed that the virus stayed in the vagina and didn\u2019t spread to other parts of the body.<\/span><\/p>\n

In contrast, the new study indicates that, after infection through the rectum, the virus rapidly spreads throughout the body. The scientists also found that the virus wasn\u2019t being carried through the blood. Instead, LCMV infects the body\u2019s own immune cells, which in turn spread the virus systemically. Interestingly, this is the same dissemination process used by the HIV virus.<\/span><\/p>\n

\u201cOur group was the first to recreate and compare these natural routes of viral infection,\u201d said Martin Trapecar, PhD, first author of the study and former postdoctoral scholar in Sanjabi\u2019s laboratory at Gladstone. \u201cWe concluded that the initial immune response elicited depends on the route of infection, and can actually dictate the dissemination of the virus. This is a novel concept, because we used to think once the virus entered the body, it would simply get into the blood and spread.\u201d<\/span><\/p>\n

The researchers revealed that mucosal barriers have different tolerance mechanisms that affect the immune system\u2019s response to invading pathogens. In addition, they showed that once a virus breaches one of the barriers, early events in the body\u2019s response to that virus can play a key role in determining the outcome of an infection.<\/span><\/p>\n

The new study provides a much better understanding of how the immune system responds to a pathogen to protect the body and how a virus spreads once it enters the vaginal or rectal mucosa. These findings have general implications for the mechanism of sexual transmission and dissemination of many viruses, including HIV and Zika.<\/span><\/p>\n

\u201cKnowing the route each virus takes when it infects people is important,\u201d said Sanjabi, who is also an assistant professor of microbiology and immunology at UC San Francisco. \u201cOur findings could change the way other scientists study viruses, and might ultimately be key to targeting treatments.\u201d<\/span><\/p>\n

Results from Sanjabi\u2019s study could also impact efforts to develop vaccines against various viruses. Recognizing the differences in immune response will be crucial to defend people who may get infected through various routes of sexual transmission.<\/span><\/p>\n

Source:\u00a0Gladstone Institutes<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

A person is more likely to get infected by HIV through anal intercourse than vaginal, but no one knows quite why. A new study by scientists at the Gladstone Institutes shows that infection sites could affect the immune system\u2019s response to a virus and the way the virus spreads through the body. The study, published […]<\/p>\n","protected":false},"author":6,"featured_media":14628,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26,17],"tags":[],"class_list":["post-14627","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",1280,512,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured-300x120.jpg",300,120,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured-768x307.jpg",750,300,true],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured-1024x410.jpg",750,300,true],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",1280,512,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",1280,512,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",1200,480,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",870,348,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",600,240,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",600,240,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",760,304,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",550,220,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",95,38,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",640,256,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",96,38,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2018\/03\/HIV-blood-vials_shutterstock_featured.jpg",150,60,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Medicine<\/a> Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/14627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=14627"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/14627\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/14628"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=14627"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=14627"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=14627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}