{"id":19363,"date":"2020-10-27T06:27:00","date_gmt":"2020-10-27T00:42:00","guid":{"rendered":"https:\/\/www.revoscience.com\/en\/?p=19363"},"modified":"2020-10-27T06:28:08","modified_gmt":"2020-10-27T00:43:08","slug":"why-bats-excel-as-viral-reservoirs-without-getting-sick","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/why-bats-excel-as-viral-reservoirs-without-getting-sick\/","title":{"rendered":"Why bats excel as viral reservoirs without getting sick"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"675\" height=\"450\" sizes=\"auto, (max-width: 675px) 100vw, 675px\" src=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-675x450.jpg\" alt=\"\" class=\"wp-image-19364\" title=\"\" srcset=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-675x450.jpg 675w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-599x400.jpg 599w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-768x512.jpg 768w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-174x116.jpg 174w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg 1100w\" \/><figcaption>\u00a0Zhu Feng, Duke-NUS Medical School<\/figcaption><\/figure>\n\n\n\n<p><strong>Singapore\u00a0(Researchsea)\u2013<\/strong> Bats act as reservoirs of numerous zoonotic viruses, including SARS-CoV, MERS CoV, Ebola virus, and\u2014most likely\u2014SARS-CoV-2, the pathogen behind the ongoing coronavirus pandemic. However, the molecular mechanisms bats deploy to tolerate pathogenic viruses has remained unclear.<\/p>\n\n\n\n<p>Now scientists from<a href=\"https:\/\/www.duke-nus.edu.sg\/about\/media\/media-releases\/media-releases\/why-bats-excel-as-viral-reservoirs-without-getting-sick\" target=\"_blank\" rel=\"noreferrer noopener\"> Duke-NUS Medical School, Singapore<\/a>, find out novel molecular mechanisms that allow bats to tolerate zoonotic viruses without getting sick. Published this week in the\u00a0<em>Proceedings of the National Academy of Sciences<\/em>\u00a0(PNAS), the study suggests that bats adopt unique strategies to prevent overactive immune responses, which protects them against diseases caused by zoonotic viruses.<\/p>\n\n\n\n<p>&nbsp;The team examined three bat species\u2014<em>Pteropus alecto<\/em>&nbsp;(black fruit bat),&nbsp;<em>Eonycteris spelaea<\/em>&nbsp;(cave nectar bat), and&nbsp;<em>Myotis davidii<\/em>&nbsp;(David&#8217;s myotis bat)\u2014and identified mechanisms that balance the activity of key proteins that play a major role in mediating immunity and inflammatory responses in mammals. These mechanisms enable bats to harbour and transmit zoonotic pathogens without setting off the detrimental consequences of immune activation.<\/p>\n\n\n\n<p>One of the mechanisms bats use is to reduce the levels of caspase-1, a protein that triggers a key inflammatory cytokine protein, interleukin-1 beta (IL-1\u03b2). Another mechanism they employ hampers the maturation of IL-1\u03b2 cytokines through a finely-tuned balancing between caspase-1 and IL-1\u03b2.<\/p>\n\n\n\n<p>&nbsp;\u201cSuppression of overactive inflammatory responses improves longevity and prevents age-related decline in humans. Our findings may offer potential insights to the development of new therapeutic strategies that can control and treat human infectious diseases,\u201d said Professor Wang Linfa, senior and corresponding author of the study from Duke-NUS\u2019 Emerging Infectious Diseases (EID) Programme.<\/p>\n\n\n\n<p>&nbsp;&#8220;This study exemplifies the world-class research led by our talented faculty to advance fundamental scientific knowledge. Professor Wang\u2019s research is all the more important in the context of COVID-19, by contributing to a greater understanding of how zoonotic diseases persist in nature, and potentially aiding new approaches to managing future outbreaks,\u201d said Professor Patrick Casey, Senior Vice-Dean for Research, Duke-NUS Medical School.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bats act as reservoirs of numerous zoonotic viruses, including SARS-CoV, MERS CoV, Ebola virus, and\u2014most likely\u2014SARS-CoV-2, the pathogen behind the ongoing coronavirus pandemic. <\/p>\n","protected":false},"author":2,"featured_media":19364,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-19363","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg",1100,734,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-200x200.jpg",200,200,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-599x400.jpg",599,400,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-768x512.jpg",750,500,true],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-675x450.jpg",675,450,true],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg",1100,734,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg",1100,734,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg",1100,734,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg",854,570,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg",600,400,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg",600,400,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-760x490.jpg",760,490,true],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-550x360.jpg",550,360,true],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea-95x65.jpg",95,65,true],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg",640,427,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg",96,64,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2020\/10\/Espelaea.jpg",150,100,false]},"author_info":{"info":["RevoScience"]},"category_info":"<a href=\"https:\/\/www.revoscience.com\/en\/category\/news\/research\/\" rel=\"category tag\">Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/19363","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=19363"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/19363\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/19364"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=19363"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=19363"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=19363"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}