{"id":20288,"date":"2021-03-29T08:30:00","date_gmt":"2021-03-29T02:45:00","guid":{"rendered":"https:\/\/www.revoscience.com\/en\/?p=20288"},"modified":"2021-03-28T20:45:32","modified_gmt":"2021-03-28T15:00:32","slug":"individual-sars-cov-2-neutralising-antibody-immunity-lasts-from-days-to-decades","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/individual-sars-cov-2-neutralising-antibody-immunity-lasts-from-days-to-decades\/","title":{"rendered":"Individual SARS-CoV-2 neutralising antibody immunity lasts from days to decades"},"content":{"rendered":"\n
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Singapore \u2013<\/strong>\u00a0Scientists from Duke-NUS Medical School, the National Centre for Infectious Diseases (NCID) and the Agency for Science, Technology and Research (A*STAR) Infectious Diseases Labs found that antibodies against SARS-CoV-2 wane at different rates, lasting for mere days in some individuals, while remaining present in others for decades. <\/p>\n\n\n\n

The study was published in\u00a0The Lancet Microbe<\/a><\/em>, shows that the severity of the infection could be a deciding factor in having longer-lasting antibodies. Individuals with low levels of neutralising antibodies may still be protected from COVID-19 if they have a robust T-cell immunity.<\/p>\n\n\n\n

The team followed 164 COVID-19 patients in Singapore for six to nine months, analysing their blood for neutralising antibodies against SARS-CoV-2, T cells and immune system signalling molecules. They then used this data to establish a machine learning algorithm to predict the trajectories of peoples\u2019 neutralising antibodies over time.<\/p>\n\n\n\n

\u201cThe key message from this study is that the longevity of functional neutralising antibodies against SARS-CoV-2 can vary greatly and it is important to monitor this at an individual level. This work may have implications for immunity longevity after vaccination, which will be part of our follow-up studies,\u201d said Professor Wang Linfa, from Duke-NUS\u2019 Emerging Infectious Diseases (EID) Programme, a corresponding author of the study.<\/p>\n\n\n\n

The team was able to categorise people into five groups depending on how long their antibodies lasted. The first group, who never developed detectable neutralising antibodies also called the \u2018negative\u2019 group, comprised 11.6 per cent of the patients in the study. <\/p>\n\n\n\n

Study shows that antibody longevity varies widely from 40 days to as long as several decades and not everyone who has recovered from COVID-19 is immune from reinfection. Individuals with low levels of neutralising antibodies may still be protected if they have robust T-cell immunity. Blood tests and a computer algorithm suggest annual vaccinations might be needed for some individuals to prevent future outbreaks of COVID-19.<\/strong><\/p><\/blockquote>\n\n\n\n

The \u2018rapid waning\u2019 group (26.8 per cent) had varying early levels of antibodies that waned quickly. The \u2018slow waning\u2019 group (29 per cent) tested mostly positive for antibodies at six months. The \u2018persistent\u2019 group (31.7 per cent) showed little change in their antibody levels up to 180 days and, finally, the \u2018delayed response\u2019 group (1.8 per cent) showed a marked rise in neutralising antibodies during late convalescence.<\/p>\n\n\n\n

While this study focused on determining the levels of neutralising antibodies, which are part of the body\u2019s comprehensive immune defence system, the other important aspect of an effective immune defence is T-cell immunity. The study found that the patients tested, including those from the \u2018negative group\u2019, displayed sustained T-cell immunity six months after initial infection. This shows that individuals may still be protected if they have a robust T-cell immunity when the neutralising antibody level is low.<\/p>\n\n\n\n

\u201cOur study examines neutralising antibodies which are important in protection from COVID-19. We found that antibodies against SARS-CoV-2 wane in different people at different rates. This emphasises the importance of public health and social measures in ongoing pandemic outbreak response. <\/p>\n\n\n\n

However, the presence of T-cell immunity provides hope of longer-term protection which will require more studies and time for epidemiological and clinical evidence to confirm,\u201d said Associate Professor David Lye, Director, Infectious Disease Research and Training Office, NCID, also a corresponding author of the study.<\/p>\n\n\n\n

\u201cThis study reminds us that we all react differently to infection and that various people mount different protective immune responses. Understanding the basis of these differences will help build better vaccines,\u201d added Professor Laurent Renia, Executive Director, A*STAR Infectious Diseases Labs.<\/p>\n\n\n\n

The findings are important as policy makers design vaccination programs and pandemic exit strategies. The rate of antibody waning suggests re-infection may occur in subsequent waves of infection. <\/p>\n\n\n\n

In-addition, if immunity provided via vaccinations wanes like naturally-produced antibodies, then annual vaccine administration could be necessary to prevent future outbreaks of COVID-19. Further research will be needed to clarify this as vaccine programs are rolled out.<\/p>\n","protected":false},"excerpt":{"rendered":"

Scientists from Duke-NUS Medical School, the National Centre for Infectious Diseases (NCID) and the Agency for Science, Technology and Research (A*STAR) Infectious Diseases Labs found that antibodies against SARS-CoV-2 wane at different rates, lasting for mere days in some individuals, while remaining present in others for decades.<\/p>\n","protected":false},"author":2,"featured_media":20289,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16,17],"tags":[],"class_list":["post-20288","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biology","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press.jpg",1100,735,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press-200x200.jpg",200,200,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press-599x400.jpg",599,400,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press-768x513.jpg",750,501,true],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press-675x451.jpg",675,451,true],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press.jpg",1100,735,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press.jpg",1100,735,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press.jpg",1100,735,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press.jpg",853,570,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press.jpg",600,401,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press.jpg",600,401,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press-760x490.jpg",760,490,true],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press-550x360.jpg",550,360,true],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press-95x65.jpg",95,65,true],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press.jpg",640,428,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press.jpg",96,64,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2021\/03\/sars-cov-2-research-press.jpg",150,100,false]},"author_info":{"info":["RevoScience"]},"category_info":"Biology<\/a> Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/20288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=20288"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/20288\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/20289"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=20288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=20288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=20288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}