{"id":2108,"date":"2015-01-14T09:53:48","date_gmt":"2015-01-14T09:53:48","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=2108"},"modified":"2015-01-14T09:53:48","modified_gmt":"2015-01-14T09:53:48","slug":"fructose-is-more-toxic-to-mice-than-table-sugar","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/fructose-is-more-toxic-to-mice-than-table-sugar\/","title":{"rendered":"Fructose is more toxic to mice than table sugar"},"content":{"rendered":"

\"TOP<\/a>University of Utah biologists perform an experiment over mice by feeding them\u00a0sugar in doses proportional to actual amount, of which most of the people normally consume in their daily life. Through this experiment researchers discovered that\u00a0the fructose-glucose mixture found in high-fructose corn syrup is more toxic than sucrose or table sugar which can result in reduction of both the reproduction and lifespan of female rodents.<\/span><\/p>\n

Biology professor Wayne Potts said\u00a0\u201cThis is the most robust study showing there is a difference between high-fructose corn syrup and table sugar at human-relevant doses,\u201d . He is the\u00a0senior author of a new study scheduled for publication in the March 2015 issue of\u00a0The Journal of Nutrition<\/em>.<\/span><\/p>\n

The study found no differences in survival, reproduction or territoriality of male mice on the high-fructose and sucrose diets. The researchers say that may be because both sugars are equally toxic to male mice.<\/span><\/p>\n

Both high-fructose corn syrup found in many processed foods and table sugar found in baked goods contain roughly equal amounts of fructose and glucose. But in corn syrup, they are separate molecules, called monosaccharides. In contrast, sucrose or table sugar is a disaccharide compound formed when fructose and glucose bond chemically.<\/span><\/p>\n

Potts says the debate over the relative dangers of fructose and sucrose is important \u201cbecause when the diabetes-obesity-metabolic syndrome epidemics started in the mid-1970s, they corresponded with both a general increase in consumption of added sugar and the switchover from sucrose being the main added sugar in the American diet to high-fructose corn syrup making up half our sugar intake.\u201d<\/span><\/p>\n

James Ruff, the study\u2019s first author and a postdoctoral fellow in biology, says, \u201cOur previous work and plenty of other studies have shown that added sugar in general is bad for your health. So first, reduce added sugar across the board. Then worry about the type of sugar, and decrease consumption of products with high-fructose corn syrup.\u201d<\/span><\/p>\n

The new study is the latest in a series that used a new, sensitive toxicity test developed by Potts and colleagues. It allows house mice to compete in the seminatural environment of room-size \u201cmouse barns.\u201d Previous mouse studies with the test found harmful effects of inbreeding, the antidepressant Paxil and, last year, an added-sugar diet with fructose and glucose in amounts proportional to a healthy human diet plus three cans of soda daily. These health effects had been missed by conventional tests.<\/span><\/p>\n

Potts and Ruff ran the new study with former University of Utah undergraduates Sara Hugentobler, Amanda Suchy, Mirtha Sosa, Ruth Tanner and Megumi Hite; and lab manager Linda Morrison. The other coauthors were nutrition researchers Sin Gieng and Mark Shigenaga at Children\u2019s Hospital Oakland Research Institute in California.<\/span><\/p>\n

The research was funded by the National Institutes of Health and National Science Foundation.<\/span><\/p>\n

New Findings Build on 2013 Sugar Toxicity Study<\/strong><\/span><\/p>\n

The 2013 study found that when mice were fed either a diet with 25 percent calories in the form of added fructose and glucose monosaccharides or 25 percent calories from starch, females died at twice the normal rate and males were a quarter less likely to hold territory and reproduce.<\/span><\/p>\n

The new study compared two groups of mice that were fed a healthy diet with 25 percent calories from processed sugars. One group ate a mix of fructose-glucose monosaccharides like those in high-fructose corn syrup. The other group ate sucrose.<\/span><\/p>\n

Female mice on the fructose-glucose diet had death rates 1.87 times higher than females on the sucrose diet. They also produced 26.4 percent fewer offspring.<\/span><\/p>\n

The new study found no differences in males on the two diets in terms of survival, reproduction or ability to compete for territory. But Potts said the 2013 study showed male mice were a quarter less likely to hold territory and reproduce on the fructose-glucose mix compared with starch. That, combined with the new findings, \u201csuggests sucrose is as bad for males as high-fructose corn syrup,\u201d he says.<\/span><\/p>\n

Ruff says it also is possible that \u201cother factors are more important than the differences between these two diets for the males\u201d \u2013 possibly inherited differences in ability to hold territory.<\/span><\/p>\n

Potts says female mice that ate the fructose-glucose mixture may be more likely to die than male mice because they undergo a bigger metabolic \u201cenergy crunch\u201d during such studies: on the day they give birth, they mate and conceive the next litter, so they are nursing their first litter while gestating a second litter.<\/span><\/p>\n

Regardless of sex, the researchers also found no difference between mice on the two diets when it came to food intake, weight gain or glucose tolerance. Sucrose is broken into fructose and glucose monosaccharides before the body absorbs it. So whatever caused the different mortality and reproduction in females on the two kinds of sugar diets, \u201cit has to happen at the point of absorption or before \u2013 not once it is in the bloodstream, liver or brain,\u201d Ruff says.<\/span><\/p>\n

\u201cSo we speculate that the different sugars could favor different microbes in the guts of mice. Other research has shown differences in bacterial communities in the gut to be associated with metabolic diseases in rodents and in humans. It\u2019s possible one form of sugar causes more bacteria to get across your gut than another.\u201d<\/span><\/p>\n

A Sugary American Diet<\/strong><\/span><\/p>\n

An estimated 13 percent to 25 percent of Americans eat a diet that includes 25 percent or more of calories in the form of added sugars \u2013 the percentage of added sugars consumed by mice in the new study. \u201cAdded sugars\u201d are sugars added during food processing or preparation and not already naturally in food, like in a piece of fruit.<\/span><\/p>\n

Ruff says that in the American diet, 44 percent of the added sugar is sucrose, 42 percent is high-fructose corn syrup and the remaining 14 percent includes honey, molasses, juice concentrates and agave \u2013 all of which also combine fructose and glucose (which also is known as dextrose). Yet worldwide, high-fructose corn syrup represents only about 8 percent of added sugar consumption, he adds.<\/span><\/p>\n

Ruff says a number of previous studies in rodents and people tied pure fructose consumption to metabolic problems such as insulin resistance, obesity and abnormal cholesterol and triglyceride levels. He says those studies concluded high-fructose corn syrup was worse than sucrose, but most compared sucrose only to fructose instead of a more realistic fructose-glucose mix.<\/span><\/p>\n

And \u201cthe few previous studies used much higher doses of sugars that are not particularly relevant to humans, and the effects were slight or small,\u201d Potts says.<\/span><\/p>\n

How the Study Was Performed<\/strong><\/span><\/p>\n

The mice in the new study were unrelated, house-type mice, rather than inbred lab mice, because the former compete with each other naturally. For about 40 weeks, mice were fed either the healthy diet with 25 percent of total calories as added fructose and glucose monosaccharides or as sucrose.<\/span><\/p>\n

Then 160 mice were released into six mouse barns to compete for food, territory and mates for 32 weeks. Each of the 377-square-foot mouse barns held eight to 10 male mice and 14 to 20 females.<\/span><\/p>\n

Each mouse barn was divided by wire mesh into six territories, each with either an open or protected nest box. Males competed for the better territories and protected nests. Implanted radio chips and antennas at feeders kept track of where mice fed and thus the territories they occupied. The researchers periodically checked for and removed dead mice, as well as pups so they would not breed.<\/span><\/p>\n

After eating different sugar diets before entering the mouse barns, all the mice ate the fructose-glucose monosaccharide diet while competing in the barns, where they roamed together and couldn\u2019t be kept on different diets. If there were harmful effects from the fructose-glucose diet before entering the mouse barns, they might be obscured if all the mice ate the sucrose diet once in the barns.<\/span><\/p>\n

Source: nsf gov\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

University of Utah biologists perform an experiment over mice by feeding them\u00a0sugar in doses proportional to actual amount, of which most of the people normally consume in their daily life. Through this experiment researchers discovered that\u00a0the fructose-glucose mixture found in high-fructose corn syrup is more toxic than sucrose or table sugar which can result in […]<\/p>\n","protected":false},"author":6,"featured_media":2109,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-2108","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",640,425,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse-300x199.jpg",300,199,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",640,425,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",640,425,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",640,425,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",640,425,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",640,425,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",640,425,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",600,398,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",600,398,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",640,425,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",542,360,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",95,63,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",640,425,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",96,64,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/TOP-mouse.jpg",150,100,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/2108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=2108"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/2108\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/2109"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=2108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=2108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=2108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}