{"id":2167,"date":"2015-01-18T10:34:33","date_gmt":"2015-01-18T10:34:33","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=2167"},"modified":"2015-01-18T10:34:33","modified_gmt":"2015-01-18T10:34:33","slug":"depression-behavioral-changes-may-precede-memory-loss-in-alzheimers","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/depression-behavioral-changes-may-precede-memory-loss-in-alzheimers\/","title":{"rendered":"Depression, Behavioral Changes May Precede Memory Loss in Alzheimer’s"},"content":{"rendered":"

\"shutterstock_Alzheimers-amyloid-plaque_ml_1\"<\/a>Depression and behavioral changes may occur before memory declines in people who will go on to develop Alzheimer\u2019s disease, according to new research at Washington University School of Medicine in St. Louis.<\/span><\/p>\n

\u00a0Researchers have known that many people with Alzheimer\u2019s experience depression, irritability, apathy and appetite loss but had not recognized how early these symptoms appear. Pinpointing the origins of these symptoms could be important to fully understanding Alzheimer\u2019s effects on the brain and finding ways to counteract them.<\/span><\/p>\n

\u00a0\u201cThere has been conflicting evidence on the relationship between Alzheimer\u2019s and depression,\u201d said senior author Catherine M. Roe, PhD, assistant professor of neurology. \u201cWe still don\u2019t know whether some of these symptoms, such as irritability and sadness, are due to people realizing on some level that they are having problems with memory and thinking, or whether these symptoms are caused directly by Alzheimer\u2019s effects on the brain.\u201d<\/span><\/p>\n

\u00a0The study appears in\u00a0Neurology<\/em>.<\/span><\/p>\n

\u00a0Roe and her colleagues at the university\u2019s Charles F. and Joanne Knight Alzheimer\u2019s Disease Research Center analyzed data on 2,416 people ages 50 and older. Scientists regularly evaluated the participants for up to seven years, including how they performed in extensive tests of mental function and psychological health.<\/span><\/p>\n

All of the participants were cognitively normal at the start, but over the course of the study, 1,218 of them developed dementia.\u00a0<\/span><\/p>\n

\u00a0Those who developed dementia during the study were more likely to have mood and behavioral changes first. For example, four years into the study, 30 percent of those who would go on to develop dementia had developed depression. In comparison, after the same period of time, only 15 percent of those who did not develop dementia during the study had become depressed. In addition, those who would go on to develop dementia were more than 12 times as likely to have delusions than those who did not develop dementia.\u00a0<\/span><\/p>\n

\u00a0Alzheimer\u2019s researchers have been working to develop markers they can use to diagnose disease before the onset of dementia. The hope is to begin treating the condition before patients develop dementia.<\/span><\/p>\n

\u00a0However, Roe cautioned that the mood changes will not work well as markers in this regard until researchers better understand how these changes are connected to the disease.<\/span><\/p>\n

Source:\u00a0Washington University in St. Louis<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Depression and behavioral changes may occur before memory declines in people who will go on to develop Alzheimer\u2019s disease, according to new research at Washington University School of Medicine in St. Louis. \u00a0Researchers have known that many people with Alzheimer\u2019s experience depression, irritability, apathy and appetite loss but had not recognized how early these symptoms […]<\/p>\n","protected":false},"author":6,"featured_media":2169,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-2167","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1-300x217.jpg",300,217,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",90,65,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",320,232,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",96,70,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/01\/shutterstock_Alzheimers-amyloid-plaque_ml_1.jpg",150,109,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/2167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=2167"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/2167\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/2169"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=2167"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=2167"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=2167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}