{"id":2427,"date":"2015-02-01T08:08:54","date_gmt":"2015-02-01T08:08:54","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=2427"},"modified":"2015-02-01T08:08:54","modified_gmt":"2015-02-01T08:08:54","slug":"biomaterial-coating-raises-prospect-of-more-successful-medical-implants","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/biomaterial-coating-raises-prospect-of-more-successful-medical-implants\/","title":{"rendered":"Biomaterial coating raises prospect of more successful medical implants"},"content":{"rendered":"

A novel, bacteria-repelling coating material that could increase the success of medical implants has been created by researchers.<\/strong><\/em><\/span><\/p>\n

\"implant-fullsize\"<\/a>The material helps healthy cells \u2018win the race\u2019 to the medical implant, beating off competition from bacterial cells and thus reducing the likelihood of the implant being rejected by the body.<\/span>

The first results of the material\u2019s performance have been published on 30 January in IOP Publishing\u2019s journal Biomedical Materials.<\/span>

The failure rate of certain medical implants still remains high\u2014around 40% for hip implants\u2014due to the formation of biofilms when the implant is first inserted into the body.<\/span>

This thin film is composed of a group of microorganisms stuck together and can be initiated by bacteria sticking to the implant. This prevents healthy cells from attaching and results in the body eventually rejecting the implant, potentially leading to serious complications for patients.<\/span>

In their study, researchers from A*STAR (Agency for Science, Technology and Research) in Singapore, Nanyang Technological University and City University of Hong Kong produced a material that not only repelled bacteria but also attracted healthy cells.<\/span>

The base of the material was made from polyelectrolyte multilayers onto which a number of specific bonding molecules, called ligands, were attached.<\/span>

After testing various concentrations of different ligands, the researchers found that RGD peptide was particularly effective at inhibiting the attachment of bacterial cells and attracting healthy cells, compared with collagen, when attached to dextran sulfate and chitosan multilayers.<\/span><\/p>\n

This combination was tested on cultures of healthy fibroblast cells and cultures of bacterial cells, in which two specific strains were used\u2014E. coli and S. aureus.<\/span>

The lead author of the research, Professor Vincent Chan from Nanyang Technological University, said: \u201cThe method we developed helped the host cells win the so called \u2018race-for-surface\u2019 battle, forming a confluent layer on the implant surface which protects it from possible bacterial adhesion and colonization.<\/span>

\u201cMedical implants currently have antibacterial silver coatings incorporated into them; however, the total amount of silver used must be very carefully controlled because high concentrations could kill mammalian cells and become toxic to the human body.<\/span>

\u201cThe bio-selective coatings we\u2019ve created do not have this problem as the materials used are non-toxic and the preparation process uses water as a solvent.<\/span>

\u201cAt the moment this is just a \u2018proof-of-concept\u2019 study, so there is still a long way to go before the coating can be used on implants in clinical setting. In future studies we hope to firstly improve the long-term stability of the coating.\u201d<\/span><\/p>\n

Key words<\/strong><\/p>\n

implant<\/strong>:<\/span>\u00a0insert or fix (tissue or an artificial object) in a person’s body, especially by surgery.<\/span><\/em><\/p>\n

biofilms<\/span><\/strong>:\u00a0<\/span>a thin but robust layer of mucilage adhering to a solid surface and containing a community of \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 bacteria and other microorganisms.<\/em><\/p>\n

Polyelectrolyte:<\/strong><\/span>\u00a0<\/span>a polymer which has several ionizable groups along the molecule, especially any of those \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 used for coagulating and flocculating particles during water treatment or for making \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 electrophoretic gels.<\/em><\/p>\n

ligands<\/strong><\/span>:\u00a0a molecule that binds to another (usually larger) molecule.<\/span><\/em><\/span><\/p>\n

collagen<\/strong><\/span>:\u00a0<\/span>the main structural protein found in animal connective tissue, yielding gelatin when boiled.<\/em><\/p>\n

dextran<\/strong><\/span>:\u00a0a carbohydrate gum formed by the fermentation of sugars and consisting of polymers of glucose.<\/span><\/em><\/span><\/p>\n

 <\/p>\n

 <\/p>\n

\n","protected":false},"excerpt":{"rendered":"

A novel, bacteria-repelling coating material that could increase the success of medical implants has been created by researchers. The material helps healthy cells \u2018win the race\u2019 to the medical implant, beating off competition from bacterial cells and thus reducing the likelihood of the implant being rejected by the body.The first results of the material\u2019s performance […]<\/p>\n","protected":false},"author":6,"featured_media":2428,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-2427","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",74,65,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",285,250,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",96,84,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/implant-fullsize.jpg",150,132,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Medicine<\/a>","tag_info":"Medicine","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/2427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=2427"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/2427\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/2428"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=2427"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=2427"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=2427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}