{"id":2602,"date":"2015-02-11T09:59:41","date_gmt":"2015-02-11T09:59:41","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=2602"},"modified":"2015-02-11T09:59:41","modified_gmt":"2015-02-11T09:59:41","slug":"impact-of-obesity-on-fertility-can-be-reversed","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/impact-of-obesity-on-fertility-can-be-reversed\/","title":{"rendered":"Impact of Obesity on Fertility Can be Reversed"},"content":{"rendered":"

\"150210083539-large\"<\/a>In a breakthrough discovery, researchers at the University of Adelaide have revealed how damage from obesity is passed from a mother to her children, and also how that damage can be reversed.<\/span><\/p>\n

The findings, by a team led by the University’s Robinson Research Institute, have major implications for the future of fertility research and are published in the journal\u00a0Development.<\/em>\u00a0\u00a0<\/span><\/p>\n

“It’s now well established that obesity in females leads to very serious fertility problems, including the inability to conceive.\u00a0 Obesity can also result in altered growth of babies during pregnancy, and it permanently programs the metabolism of offspring, passing the damage caused by obesity from one generation to the next,” said lead author Associate Professor Rebecca Robker from the Robinson Research Institute.<\/span><\/p>\n

“In our laboratory studies, we’ve been able to unravel a key mechanism that leads to this multi-generational damage, and we’ve found a way to stop it happening,” Associate Professor Robker said.<\/span><\/p>\n

The research team found that obesity leads to a particular stress response that causes damage to the mitochondria, which are critical energy-producing ‘organs’ within living cells. \u00a0<\/span><\/p>\n

“All of the mitochondria in our bodies come from our mother.\u00a0 If the mother is obese, this\u00a0 produces stresses that lead to reduced transmission of mitochondria to the offspring.\u00a0 We found that the eggs of such mothers lead to heavier-than-normal fetuses with greatly reduced amounts of mitochondrial DNA and other obvious signs of damage,” she said.<\/span><\/p>\n

Having pinpointed the problem, Associate Professor Robker and her colleagues attempted to stop it from occurring.<\/span><\/p>\n

“Once we had identified the type of stress involved, we used compounds known to alleviate that stress in the cells.\u00a0 In particular, we were interested in compounds that are also being tested in diabetes clinical trials,” Associate Professor Robker said.<\/span><\/p>\n

“These compounds were highly successful in preventing the stress response, thereby stopping the damage from obesity being passed onto the offspring.\u00a0 It restored egg quality, embryo development and mitochondrial DNA to levels equivalent to those of a healthy mother.\u00a0 Effectively, the problem was fully reversed.” \u00a0<\/span><\/p>\n

Associate Professor Robker said the results of this work point towards a potential future therapy to restore “natural” fertility in obese women, and to prevent multi-generational damage passing onto their children.<\/span><\/p>\n

“Importantly, this work further highlights that a woman’s nutritional state prior to getting pregnant matters greatly.\u00a0 Women are urged to eat healthy diets to optimise their chances for a healthy conception and to reduce the potential impact on their child’s future health,” she said.<\/span><\/p>\n

Source:\u00a0<\/span>University of Adelaide<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

In a breakthrough discovery, researchers at the University of Adelaide have revealed how damage from obesity is passed from a mother to her children, and also how that damage can be reversed. The findings, by a team led by the University’s Robinson Research Institute, have major implications for the future of fertility research and are […]<\/p>\n","protected":false},"author":6,"featured_media":2603,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-2602","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",744,645,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large-300x260.jpg",300,260,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",744,645,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",744,645,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",744,645,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",744,645,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",744,645,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",657,570,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",600,520,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",600,520,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",565,490,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",415,360,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",75,65,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",640,555,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",96,83,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/02\/150210083539-large.jpg",150,130,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/2602","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=2602"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/2602\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/2603"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=2602"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=2602"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=2602"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}