{"id":26601,"date":"2025-06-17T13:57:37","date_gmt":"2025-06-17T08:12:37","guid":{"rendered":"https:\/\/www.revoscience.com\/en\/?p=26601"},"modified":"2025-06-17T13:57:41","modified_gmt":"2025-06-17T08:12:41","slug":"illuminated-changes-enhancing-d-lactic-acid-output-with-uv-irradiation","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/illuminated-changes-enhancing-d-lactic-acid-output-with-uv-irradiation\/","title":{"rendered":"Illuminated changes: Enhancing D-lactic acid output with UV irradiation"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"524\" src=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada.webp\" alt=\"\" class=\"wp-image-26602\" style=\"width:840px;height:auto\" title=\"\" srcset=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada.webp 700w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-675x505.webp 675w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-150x112.webp 150w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Amid concerns over rising petroleum prices and resource depletion, organic compounds such as methanol are attracting attention as potential replacements. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Though this bodes well in theory, the production of raw materials from methanol relies on costly chemical processes. An energy-saving, bio-based process is necessary for fully tapping into this resource.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To make this a reality, Associate Professor Ryosuke Yamada\u2019s team at Osaka Metropolitan University\u2019s Graduate School of Engineering has developed a&nbsp;<em>Komagataella phaffii<\/em>&nbsp;(<em>K. phaffii<\/em>) yeast strain that can efficiently produce D-lactic acid, a raw material for pharmaceuticals and bioplastics, from methanol.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In their research, the team employed ultraviolet irradiation to damage the DNA of K. phaffii cells and induce gene mutations, thereby enhancing D-lactic acid production. The exposure to ultraviolet rays successfully created a new strain, DLac_Mut2_221, that produces approximately 1.5 times more D-lactic acid.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cFurther, we performed genetic analyses using next-generation sequencers and identified the genes involved in improving D-lactic acid productivity,\u201d stated Professor Yamada. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cGoing forward, we plan to further improve the efficiency of D-lactic acid production from\u00a0<em>K. phaffii<\/em>\u00a0and develop technologies for producing other useful compounds from methanol.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Amid concerns over rising petroleum prices and resource depletion, organic compounds such as methanol are attracting attention as potential replacements. <\/p>\n","protected":false},"author":2,"featured_media":26602,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-26601","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada.webp",700,524,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-200x200.webp",200,200,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-675x505.webp",675,505,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada.webp",700,524,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada.webp",700,524,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada.webp",700,524,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada.webp",700,524,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada.webp",700,524,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada.webp",700,524,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-600x524.webp",600,524,true],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-600x524.webp",600,524,true],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-700x490.webp",700,490,true],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-550x360.webp",550,360,true],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-95x65.webp",95,65,true],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-640x524.webp",640,524,true],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-96x96.webp",96,96,true],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/06\/Low-Res_Yamada-150x112.webp",150,112,true]},"author_info":{"info":["RevoScience"]},"category_info":"<a href=\"https:\/\/www.revoscience.com\/en\/category\/news\/research\/\" rel=\"category tag\">Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/26601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=26601"}],"version-history":[{"count":1,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/26601\/revisions"}],"predecessor-version":[{"id":26603,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/26601\/revisions\/26603"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/26602"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=26601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=26601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=26601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}