{"id":27541,"date":"2025-08-15T12:21:35","date_gmt":"2025-08-15T06:36:35","guid":{"rendered":"https:\/\/www.revoscience.com\/en\/?p=27541"},"modified":"2025-08-15T12:21:38","modified_gmt":"2025-08-15T06:36:38","slug":"new-method-more-accurately-assesses-movement-disorder-in-children","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/new-method-more-accurately-assesses-movement-disorder-in-children\/","title":{"rendered":"New method more accurately assesses movement disorder in children"},"content":{"rendered":"\n
\"\"
Bhooma Aravamuthan, MD, a pediatric movement disorders specialist, sees pediatric cerebral palsy patients at West County on August 14, 2023. MATT MILLER\/WUSM<\/sup><\/em><\/figcaption><\/figure>\n\n\n\n

Cerebral palsy affects around one in 345 children in the U.S., and more than half of them experience a problem called dystonia\u2014involuntary and often painful muscle contractions, most commonly in the legs, that lead to abnormal movement and postures and make regular activities such as walking difficult.<\/p>\n\n\n\n

Traditionally, doctors have relied on subjective assessment for diagnosing dystonia, which can be inconsistent and lead to delayed treatment. For children with cerebral palsy, this delay can result in their condition worsening and becoming more difficult to treat.<\/p>\n\n\n\n

Now, an interdisciplinary research team led by\u00a0Bhooma Aravamuthan, MD, DPhil<\/a>, an assistant professor of neurology at Washington University School of Medicine in St. Louis, has identified an objective way of measuring leg dystonia in children with cerebral palsy. <\/p>\n\n\n\n

Their method evaluates leg movement variability\u2014specifically, the extent to which a child\u2019s legs adduct, or move toward the center of the body, while they\u2019re sitting down. With this straightforward method, doctors can quickly and accurately determine the severity of dystonia in their patients and tailor treatments to their needs.<\/p>\n\n\n\n

In an effort to better understand the causes of dystonia, the researchers then identified in mice the conditions and brain region linked with leg movement variability, suggesting that early medical intervention targeting the relevant brain processes could effectively treat or even prevent this common complication.<\/p>\n\n\n\n

The results were published online July 3 in Annals of Neurology<\/a><\/em>.<\/p>\n\n\n\n

\u201cAn overarching goal of this work is about standardizing dystonia assessment by quantifying diagnoses that were previously based on doctors\u2019 gut feelings,\u201d said Aravamuthan, who started the project while being mentored in the lab of co-senior author Jordan McCall, PhD<\/a>, an associate professor of anesthesiology at WashU Medicine. \u201cThese results can be immediately put into clinical practice to help guide treatment selection for children with cerebral palsy and ultimately improve patient outcomes.\u201d<\/p>\n\n\n\n

Leveraging technology to measure movement<\/h2>\n\n\n\n

Despite being a common feature of cerebral palsy, dystonia has proven difficult to pin down in earlier research because of its variability of symptoms, which may be subtle and only appear during specific activities or when a child is stressed. <\/p>\n\n\n\n

Inspired by her work with pediatric neurology patients, Aravamuthan and her collaborators set out to both quantify the clinical presentation of leg dystonia and determine its causal mechanism in the brain, with the goal of making standardized evaluation and treatment available for patients immediately.<\/p>\n\n\n\n

Aravamuthan\u2019s study had two main parts. First, a panel of eight pediatric movement disorder specialists practicing at different institutions across the U.S. watched videos of 193 children ages three and up with cerebral palsy performing a seated task with their hands. <\/p>\n\n\n\n

They found that the variability in the child\u2019s leg movements correlated strongly with the severity of their dystonia as assessed from the videos, suggesting that this variability\u2014which is objectively and quantitatively measurable in an office setting in terms of the angle and position of the child\u2019s legs as they move toward the midline of the body\u2014could be used as a reliable marker of the disorder.<\/p>\n\n\n\n

\u201cWe were able to establish concrete guidelines that physicians can use today to evaluate dystonia in patients with cerebral palsy more accurately,\u201d said Aravamuthan. \u201cThat will make treatment better for our patients as well as support drug development and future research that can rely on this consistent and reproducible assessment method.\u201d<\/p>\n\n\n\n

In the second part of the study, Aravamuthan\u2019s team tested whether stimulating specialized brain cells in the region associated with motor control could cause similar leg movement variability in mice as that observed in people. These cells, called striatal cholinergic interneurons (ChIs), play a key role in coordinating muscle movements and ensuring smooth and purposeful actions, making them a promising target for developing treatments for dystonia.<\/p>\n\n\n\n

Researchers in Aravamuthan\u2019s lab selectively excited these neurons in mice over 14 days. They observed that mice with chronic ChI excitation displayed increased leg movement variability compared to mice without ChI excitation, mimicking the dystonia seen in people with cerebral palsy. <\/p>\n\n\n\n

This did not happen with short-term excitation, showing that sustained activity in these neurons is necessary to produce the dystonia. This suggests that drugs that target overactive striatal ChIs could be a promising approach for treating dystonia.<\/p>\n\n\n\n

\u201cWe know from the clinic that it takes weeks, months, or sometimes even years after brain injury for someone to develop dystonia,\u201d Aravamuthan said. <\/p>\n\n\n\n

\u201cThere are medications already in use that focus on reducing the excitability of these neurons, but they\u2019re given after dystonia has already been present for a while, which may be why they\u2019re only variably effective. Our work in mice suggests that if you give these medications early and prevent chronic excitation of these neurons, you may prevent dystonia from happening.\u201d<\/p>\n\n\n\n

Aravamuthan added that additional experiments and drug trials would be required before such interventions see clinical use.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cerebral palsy affects around one in 345 children in the U.S., and more than half of them experience a problem called dystonia\u2014involuntary and often painful muscle contractions, most commonly in the legs, that lead to abnormal movement and postures and make regular activities such as walking difficult.<\/p>\n","protected":false},"author":2,"featured_media":27542,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-27541","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final.webp",700,467,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final-200x200.webp",200,200,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final-675x450.webp",675,450,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final.webp",700,467,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final.webp",700,467,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final.webp",700,467,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final.webp",700,467,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final.webp",700,467,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final.webp",700,467,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final-600x467.webp",600,467,true],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final-600x467.webp",600,467,true],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final.webp",700,467,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final-550x360.webp",550,360,true],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final-95x65.webp",95,65,true],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final-640x467.webp",640,467,true],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final-96x96.webp",96,96,true],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/08\/Aravamuthan_dystonia_art_final-150x100.webp",150,100,true]},"author_info":{"info":["RevoScience"]},"category_info":"Health<\/a>","tag_info":"Health","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/27541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=27541"}],"version-history":[{"count":1,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/27541\/revisions"}],"predecessor-version":[{"id":27543,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/27541\/revisions\/27543"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/27542"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=27541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=27541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=27541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}