{"id":28479,"date":"2025-09-19T09:40:59","date_gmt":"2025-09-19T03:55:59","guid":{"rendered":"https:\/\/www.revoscience.com\/en\/?p=28479"},"modified":"2025-09-19T09:42:08","modified_gmt":"2025-09-19T03:57:08","slug":"migrasomes-cellular-voyagers-shaping-health-and-disease","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/migrasomes-cellular-voyagers-shaping-health-and-disease\/","title":{"rendered":"Migrasomes: Cellular Voyagers Shaping Health and Disease"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full is-resized\"><img data-dominant-color=\"f5f6f6\" data-has-transparency=\"false\" loading=\"lazy\" decoding=\"async\" width=\"699\" height=\"401\" sizes=\"auto, (max-width: 699px) 100vw, 699px\" src=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11.webp\" alt=\"\" class=\"wp-image-28480 not-transparent\" style=\"--dominant-color: #f5f6f6; width:840px;height:auto\" title=\"\" srcset=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11.webp 699w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-675x387.webp 675w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-150x86.webp 150w\" \/><figcaption class=\"wp-element-caption\"><em><sup>Generative mechanism of migrasome. Migrasome biogenesis can be divided into two steps: (i) the initial sites formation includes the generation of SMS2 foci, the recruitment of PIP5K1A, the formation of PI(4,5)P<sub>2<\/sub>, the recruitment of RAB35 and the interaction between integrin and extracellular matrix (ECM). (ii) the stabilization and maturation step includes not only the formation of swelling induced by calcium, SYT1 and tension fluctuation, but also the accumulation of TEMA for stabilization and membrane<\/sup><\/em><\/figcaption><\/figure>\n\n\n\n<p>First identified in 2015, migrasomes are a newly discovered class of membrane-bound vesicles that form along the trails of migrating cells. Measuring less than 3 \u03bcm in diameter, these tiny structures serve as dynamic cargo carriers\u2014transporting nucleic acids, proteins, organelles, and more. <\/p>\n\n\n\n<p>Acting as both molecular messengers and functional hubs, migrasomes are now recognized as key players in organ development, immune modulation, and cancer metastasis, offering fresh perspectives on disease mechanisms and therapeutic innovation.<\/p>\n\n\n\n<p>A comprehensive review by Dr. Chen Yang\u2019s team at Peking University, titled \u201cA Decade of Discovery: Tracing the Footmarks of Migrasomes, Unveiling the Footprints of Cells\u201d (published in Science China Life Sciences), outlines the mechanisms behind migrasome formation, their diverse cargo, biological roles, and the cutting-edge technologies used to study them.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Biogenesis in Two Acts:<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Stage One:<\/strong> Sphingomyelin synthase 2 (SMS2) clusters at pseudopodia, marking the nascent sites of migrasome formation. This is followed by the assembly of a PI(4,5)P2-Rab35-integrin complex, which generates mechanical tension.<\/li>\n\n\n\n<li><strong>Stage Two:<\/strong> Membrane swelling is driven by calcium-dependent SYT1, while TSPAN4-enriched microdomains (TEMAs) increase membrane stiffness, facilitating expansion and maturation.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Functional Versatility:<\/h4>\n\n\n\n<p>Once released, migrasomes engage in a wide array of physiological activities\u2014supporting organogenesis, tissue repair, angiogenesis, hemostasis, and even viral transmission. Their dual nature in disease is particularly striking: they can aid recovery by clearing damaged mitochondria or delivering beneficial signals, yet also exacerbate pathology by transferring inflammatory cytokines or harmful molecules. Importantly, migrasomes are emerging as promising non-invasive biomarkers for early disease detection.<\/p>\n\n\n\n<p>Recent innovations have significantly enhanced the efficiency of migrasome isolation and characterization. Live imaging breakthroughs now allow scientists to observe migrasome behavior in real time within living organisms. These advances are pushing the boundaries of organelle research and opening new avenues for precision medicine.<\/p>\n\n\n\n<p>Despite remarkable progress, many mysteries remain. Future investigations will delve into how retraction fibers influence spatial cargo release and explore migrasomes\u2019 specific roles in both healthy and diseased states. Unlocking their full potential will require interdisciplinary collaboration and continued innovation in multi-omics, advanced microscopy, and bioengineering.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>First identified in 2015, migrasomes are a newly discovered class of membrane-bound vesicles that form along the trails of migrating cells. <\/p>\n","protected":false},"author":2,"featured_media":28480,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-28479","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11.webp",699,401,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-200x200.webp",200,200,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-675x387.webp",675,387,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11.webp",699,401,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11.webp",699,401,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11.webp",699,401,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11.webp",699,401,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11.webp",699,401,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11.webp",699,401,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-600x401.webp",600,401,true],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-600x401.webp",600,401,true],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11.webp",699,401,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-550x360.webp",550,360,true],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-95x65.webp",95,65,true],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-640x401.webp",640,401,true],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-96x96.webp",96,96,true],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/09\/migrasomes11-150x86.webp",150,86,true]},"author_info":{"info":["RevoScience"]},"category_info":"<a href=\"https:\/\/www.revoscience.com\/en\/category\/news\/research\/\" rel=\"category tag\">Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/28479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=28479"}],"version-history":[{"count":2,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/28479\/revisions"}],"predecessor-version":[{"id":28482,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/28479\/revisions\/28482"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/28480"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=28479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=28479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=28479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}