{"id":3008,"date":"2015-03-02T07:17:52","date_gmt":"2015-03-02T07:17:52","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=3008"},"modified":"2015-03-02T07:47:32","modified_gmt":"2015-03-02T07:47:32","slug":"pancreatic-cancer-subtypes-could-guide-future-treatments","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/pancreatic-cancer-subtypes-could-guide-future-treatments\/","title":{"rendered":"Pancreatic Cancer Subtypes Could Guide Future Treatments"},"content":{"rendered":"

\"shutterstock_cancer_cell_3_6\"<\/a><\/p>\n

Scientists from Australia and the UK have completed the most comprehensive analysis yet of pancreatic cancer, in a study that could improve future treatments.<\/span><\/p>\n

The international study has revealed four\u00a0sub types\u00a0of the\u00a0disease.<\/span><\/p>\n

The research team was led by Professor Sean Grimmond from UQ\u2019s Institute for Molecular Bioscience and Professor Andrew Biankin from Sydney\u2019s Garvan Institute of Medical Research and the University of New South Wales, and included bioinformatician Dr Nicola Waddell from Brisbane\u2019s QIMR Berghofer Medical Research Institute.<\/span><\/p>\n

The analysis used a technique called whole genome sequencing to determine the complete genetic code of pancreatic tumors in 100 patients, with the data published in Nature.<\/span><\/p>\n

The team identified and mapped detailed patterns of \u2018structural variation\u2019 to reveal the extensive and damaging genetic changes that drive the formation of four cancer subtypes.<\/span><\/p>\n

Professor Grimmond said this gave researchers a deeper understanding of the complex genomic landscape of pancreatic cancer.<\/span><\/p>\n

\u201cWhole genome sequencing gave us unprecedented access to explore the history of each patient\u2019s genome, including how their genes and chromosomes had rearranged and accumulated damage over time,\u201d he said.<\/span><\/p>\n

The identification of four different subtypes meant there was potential to treat each type differently.<\/span><\/p>\n

\u201cHaving access to these detailed genetic maps could help doctors in the future determine which chemotherapy drug a patient should get, based on their cancer\u2019s genome.\u201d<\/span><\/p>\n

QIMR Berghofer bioinformatician Dr Nicola Waddell (formerly of UQ IMB) said pancreatic cancer remained one of the most complex cancers to treat.<\/span><\/p>\n

\u201cOur study identified four major genomic subtypes in pancreatic cancer, revealed two new driver genes not previously associated with pancreatic cancer, and reaffirmed the importance of five key genes.<\/span><\/p>\n

\u201cThese findings could prove promising in diagnosing and treating the disease in future.\u201d<\/span><\/p>\n

Professor Biankin and Professor Grimmond plan to conduct a clinical trial in the UK, selecting patients for targeted treatments based on genomic testing.<\/span><\/p>\n

Pancreatic cancer is the fifth-leading cause of cancer death in Australia.<\/span><\/p>\n

Source:\u00a0<\/span>University of Queensland<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Scientists from Australia and the UK have completed the most comprehensive analysis yet of pancreatic cancer, in a study that could improve future treatments. The international study has revealed four\u00a0sub types\u00a0of the\u00a0disease. The research team was led by Professor Sean Grimmond from UQ\u2019s Institute for Molecular Bioscience and Professor Andrew Biankin from Sydney\u2019s Garvan Institute […]<\/p>\n","protected":false},"author":6,"featured_media":3009,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26,17],"tags":[],"class_list":["post-3008","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6-300x180.jpg",300,180,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",95,57,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",500,300,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",96,58,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/03\/shutterstock_cancer_cell_3_6.jpg",150,90,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Medicine<\/a> Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/3008","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=3008"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/3008\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/3009"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=3008"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=3008"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=3008"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}