{"id":34034,"date":"2025-12-31T13:30:33","date_gmt":"2025-12-31T07:45:33","guid":{"rendered":"https:\/\/www.revoscience.com\/en\/?p=34034"},"modified":"2025-12-31T13:30:37","modified_gmt":"2025-12-31T07:45:37","slug":"cologne-scientists-uncover-mechanism-driving-aggressive-lung-cancer","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/cologne-scientists-uncover-mechanism-driving-aggressive-lung-cancer\/","title":{"rendered":"Cologne scientists uncover mechanism driving aggressive lung cancer"},"content":{"rendered":"\n
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IMAGE: deepai<\/sup><\/em><\/figcaption><\/figure>\n\n\n\n

COLOGNE, Dec 31 \u2013<\/strong> Scientists in Germany have identified a biological mechanism that helps explain why small cell lung cancer (SCLC), one of the most aggressive forms of lung cancer, relapses quickly despite initially responding to chemotherapy.<\/p>\n\n\n\n

A team led by Professor Silvia von Karstedt at the University of Cologne\u2019s Center for Molecular Medicine said the absence of a protein called caspase-8 triggers inflammatory cell death, creating conditions that allow tumours to spread and evade the immune system.<\/p>\n\n\n\n

\u201cWithout caspase-8, necroptosis sets in, producing inflammation even before tumours form,\u201d von Karstedt said. \u201cThis inflammation suppresses the body\u2019s anti-cancer immune response and can promote metastasis.\u201d<\/p>\n\n\n\n

The study, published in Nature Communication<\/a>s<\/em>, found that the inflammation also reprograms cancer cells to behave like immature neuron-like cells, a state linked to relapse and rapid disease progression.<\/p>\n\n\n\n

SCLC accounts for about 15% of lung cancers and has a five-year survival rate of just 5%. While chemotherapy often works at first, patients typically relapse within months.<\/p>\n\n\n\n

The Cologne team used a genetically engineered mouse model lacking caspase-8 to mimic human SCLC. Their findings suggest that targeting pre-tumoral inflammation could improve therapies and early diagnostics, though it remains unclear if the same process occurs in human patients.<\/p>\n\n\n\n

The research was supported by the German Research Foundation under Collaborative Research Centre 1399, which focuses on drug sensitivity and resistance in SCLC.<\/p>\n","protected":false},"excerpt":{"rendered":"

COLOGNE, Dec 31 \u2013 Scientists in Germany have identified a biological mechanism that helps explain why small cell lung cancer (SCLC), one of the most aggressive forms of lung cancer, relapses quickly despite initially responding to chemotherapy.<\/p>\n","protected":false},"author":2,"featured_media":34035,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-34034","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer.webp",768,576,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-200x200.webp",200,200,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-675x506.webp",675,506,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer.webp",750,563,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer.webp",750,563,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer.webp",768,576,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer.webp",768,576,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer.webp",768,576,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-768x570.webp",768,570,true],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-600x576.webp",600,576,true],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-600x576.webp",600,576,true],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-760x490.webp",760,490,true],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-550x360.webp",550,360,true],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-95x65.webp",95,65,true],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-640x576.webp",640,576,true],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-96x96.webp",96,96,true],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2025\/12\/small-lung-cancer-150x113.webp",150,113,true]},"author_info":{"info":["RevoScience"]},"category_info":"Health<\/a>","tag_info":"Health","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/34034","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=34034"}],"version-history":[{"count":1,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/34034\/revisions"}],"predecessor-version":[{"id":34036,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/34034\/revisions\/34036"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/34035"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=34034"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=34034"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=34034"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}