{"id":34946,"date":"2026-01-22T20:55:08","date_gmt":"2026-01-22T15:10:08","guid":{"rendered":"https:\/\/www.revoscience.com\/en\/?p=34946"},"modified":"2026-01-22T20:55:11","modified_gmt":"2026-01-22T15:10:11","slug":"new-ai-method-revolutionizes-enzyme-design-graz-researchers-say","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/new-ai-method-revolutionizes-enzyme-design-graz-researchers-say\/","title":{"rendered":"New AI method revolutionizes enzyme design, Graz researchers say"},"content":{"rendered":"\n
\"\"
Adrian Tripp, Markus Braun and Gustav Oberdorfer from the Institute of Biochemistry at TU Graz, as well as M\u00e9lanie Hall from the Institute of Chemistry at the University of Graz. Image source: IBC \u2013 TU Graz<\/sup><\/em><\/figcaption><\/figure>\n\n\n\n

GRAZ, Austria, Jan 22 \u2013<\/strong> Scientists at TU Graz and the University of Graz have developed an artificial intelligence method that they say could transform the design of enzymes, making them faster, more stable and more versatile than current artificial biocatalysts.<\/p>\n\n\n\n

The study, published in Nature<\/em>, introduces a technology called Riff-Diff (Rotamer Inverted Fragment Finder\u2013Diffusion), which allows protein structures to be built directly around active sites rather than relying on existing databases. Researchers said the resulting enzymes showed higher activity and stability, with some remaining folded at temperatures above 90 degrees Celsius.<\/p>\n\n\n\n

\u201cInstead of searching databases for structures that fit, we can now design enzymes from scratch in a one-shot process,\u201d said Gustav Oberdorfer of TU Graz, whose ERC project HELIXMOLD laid the groundwork for the breakthrough.<\/p>\n\n\n\n

From 35 tested sequences, the team produced active enzymes for different reaction types, which they said were significantly faster than earlier computer-assisted designs. The method combines generative machine learning models with atomistic modeling to achieve angstrom-level precision.<\/p>\n\n\n\n

The researchers said the advance could accelerate industrial processes, enable targeted enzyme therapies and support environmental applications such as breaking down pollutants.<\/p>\n\n\n\n

\u201cThis is a shortcut to evolution,\u201d said co-author Adrian Tripp of TU Graz. \u201cNature takes time to produce enzymes, but our approach speeds up the process dramatically.\u201d<\/p>\n\n\n\n

The project was carried out in collaboration with the University of Graz. M\u00e9lanie Hall of the university\u2019s Institute of Chemistry said the work highlighted the importance of interdisciplinary approaches in modern biocatalysis.<\/p>\n","protected":false},"excerpt":{"rendered":"

GRAZ, Austria, Jan 22 \u2013 Scientists at TU Graz and the University of Graz have developed an artificial intelligence method that they say could transform the design of enzymes, making them faster, more stable and more versatile than current artificial biocatalysts.<\/p>\n","protected":false},"author":2,"featured_media":34947,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[163],"tags":[],"class_list":["post-34946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ai"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz.webp",2000,1000,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-200x200.webp",200,200,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-675x338.webp",675,338,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-768x384.webp",750,375,true],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-1100x550.webp",750,375,true],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-1536x768.webp",1536,768,true],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz.webp",2000,1000,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-1200x800.webp",1200,800,true],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-870x570.webp",870,570,true],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-600x900.webp",600,900,true],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-600x600.webp",600,600,true],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-760x490.webp",760,490,true],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-550x360.webp",550,360,true],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-95x65.webp",95,65,true],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-640x853.webp",640,853,true],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-96x96.webp",96,96,true],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/01\/Scientists-at-TU-Graz-150x75.webp",150,75,true]},"author_info":{"info":["RevoScience"]},"category_info":"AI<\/a>","tag_info":"AI","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/34946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=34946"}],"version-history":[{"count":1,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/34946\/revisions"}],"predecessor-version":[{"id":34948,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/34946\/revisions\/34948"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/34947"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=34946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=34946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=34946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}