{"id":37399,"date":"2026-04-28T12:13:32","date_gmt":"2026-04-28T06:28:32","guid":{"rendered":"https:\/\/www.revoscience.com\/en\/?p=37399"},"modified":"2026-04-28T12:13:36","modified_gmt":"2026-04-28T06:28:36","slug":"new-framework-links-phenotype-and-target-screening-to-boost-drug-discovery-from-chinese-herbal-medicines","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/new-framework-links-phenotype-and-target-screening-to-boost-drug-discovery-from-chinese-herbal-medicines\/","title":{"rendered":"New Framework Links Phenotype and Target Screening to Boost Drug Discovery from Chinese Herbal Medicines"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"292\" src=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056.webp\" alt=\"\" class=\"wp-image-37401\" title=\"\" srcset=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056.webp 700w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-675x282.webp 675w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-150x63.webp 150w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><figcaption class=\"wp-element-caption\"><em>3D: three-dimensional;\u00a0P<sub>N<\/sub>: the probability of normal cells;\u00a0P<sub>T<\/sub>: the probability of treated cells.<\/em><\/figcaption><\/figure>\n\n\n\n<p><strong>BEIJING<\/strong> \u2013 A new research framework published in <em>Engineering<\/em> proposes a streamlined approach to drug discovery from Chinese herbal medicines (CHMs), aiming to overcome long-standing hurdles in turning natural products into approved pharmaceuticals.<\/p>\n\n\n\n<p>CHMs have been central to traditional Chinese medicine and have produced landmark drugs such as artemisinin and ephedrine. Yet only 23.5% of new drugs approved by the U.S. Food and Drug Administration over the past four decades have originated from botanical sources.<\/p>\n\n\n\n<p>Researchers say the shortfall reflects the complex chemical makeup of CHMs and their poorly understood multitarget mechanisms, which have hindered modern drug development.<\/p>\n\n\n\n<p>The study introduces a \u201cphenotype\u2013target coupled drug screening\u201d (PTDS) strategy, combining phenotypic drug discovery with target-based methods. Phenotypic screening, which identifies compounds based on functional changes rather than predefined molecular targets, has historically driven most first-in-class drug approvals. <\/p>\n\n\n\n<p>PTDS applies hierarchical phenotypic screening across molecular, cellular, tissue and organism levels to locate active compounds, then uses target deconvolution to support rediscovery through target-based approaches.<\/p>\n\n\n\n<p>Advanced technologies underpin the framework, including multiomic integration, AI-driven drug\u2013target interaction prediction, high-resolution metabolomics, spatial mass spectrometry imaging, and AI-enhanced cell painting. Organoid and organ-on-a-chip models further replicate tissue function for preclinical testing.<\/p>\n\n\n\n<p>Researchers caution that challenges remain, including data integration, AI interpretability, and limitations in organoid vascularization. Still, they argue PTDS offers a resource-efficient pipeline that narrows candidate scope, clarifies CHM efficacy, and reduces failure risks in preclinical and clinical development.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BEIJING \u2013 A new research framework published in Engineering proposes a streamlined approach to drug discovery from Chinese herbal medicines (CHMs), aiming to overcome long-standing hurdles in turning natural products into approved pharmaceuticals.<\/p>\n","protected":false},"author":2,"featured_media":37401,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26,17],"tags":[],"class_list":["post-37399","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056.webp",700,292,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-200x200.webp",200,200,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-675x282.webp",675,282,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056.webp",700,292,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056.webp",700,292,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056.webp",700,292,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056.webp",700,292,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056.webp",700,292,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056.webp",700,292,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-600x292.webp",600,292,true],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-600x292.webp",600,292,true],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056.webp",700,292,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-550x292.webp",550,292,true],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-95x65.webp",95,65,true],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-640x292.webp",640,292,true],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-96x96.webp",96,96,true],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2026\/04\/Low-Res_E26056-150x63.webp",150,63,true]},"author_info":{"info":["RevoScience"]},"category_info":"<a href=\"https:\/\/www.revoscience.com\/en\/category\/health\/medicine\/\" rel=\"category tag\">Medicine<\/a> <a href=\"https:\/\/www.revoscience.com\/en\/category\/news\/research\/\" rel=\"category tag\">Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/37399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=37399"}],"version-history":[{"count":1,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/37399\/revisions"}],"predecessor-version":[{"id":37402,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/37399\/revisions\/37402"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/37401"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=37399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=37399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=37399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}