{"id":3995,"date":"2015-04-16T10:24:48","date_gmt":"2015-04-16T10:24:48","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=3995"},"modified":"2015-04-16T10:24:48","modified_gmt":"2015-04-16T10:24:48","slug":"tumor-only-genetic-sequencing-may-mislead-cancer-therapy","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/tumor-only-genetic-sequencing-may-mislead-cancer-therapy\/","title":{"rendered":"Tumor-Only Genetic Sequencing May Mislead Cancer Therapy"},"content":{"rendered":"

\"shutterstock_218141077_0\"When it comes to sequencing patients\u2019 tumor genomes to personalize cancer therapy, one very important step may be missing, suggest Johns Hopkins researchers: a point of comparison to patients\u2019 noncancerous genomes.<\/span><\/p>\n

Without these comparisons \u2014 or a full picture of a patient\u2019s genome \u2014 nearly half of all patients may be getting the wrong cancer treatment, say the researchers at the John Hopkins Kimmel Cancer Center.<\/span><\/p>\n

\u201cBy not sequencing each person\u2019s normal tissue to filter out noncancer-related changes, it\u2019s difficult to really understand what is occurring in the tumor,\u201d said Victor Velculescu, M.D., Ph.D., a professor of oncology and pathology and co-director of the Cancer Biology Program at the Johns Hopkins University School of Medicine, in a press release.<\/span><\/p>\n

When Velculescu and colleagues compared the genomes of tumor and normal tissue from more than 800 cancer patients\u2019 sequencing data, they found that approximately 65 percent of the genetic changes identified with tumor-only genetic sequencing were \u201cfalse positives\u201d and not related to the patient\u2019s cancer. That\u2019s because, by first sequencing a patient\u2019s noncancer genome, the researchers identified which genetic changes are heritable variations.<\/span><\/p>\n

The researchers also looked at changes in \u201cactionable genes,\u201d or genes for which some drug or therapy has been identified. In this case, false positive affected 48 percent of the patients analyzed.<\/span><\/p>\n

\u201cIn tumor-only analyses, we found that nearly half of patients had tumor mutations that were actually germline or false positives in actionable genes, and they could lead to inappropriate therapy,\u201d Velculescu said.<\/span><\/p>\n

Inaccurate genetic information can lead to side effects from incorrect targeted therapies and increased costs of patient care from misdirected medicines, report the researchers.<\/span><\/p>\n

That said, Velculescu and his team acknowledge the challenges associated with implementing tumor-normal analyses in a clinical setting \u2014 including added costs of sequencing a patient\u2019s normal tissue.<\/span><\/p>\n

These study results build on the concept of\u00a0precision medicine<\/span><\/a>, in which oncology researchers hope that one day, DNA sequencing will be a reality for every cancer patient, so that patients may receive personalized therapy.<\/span><\/p>\n

Source: ddmag.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

When it comes to sequencing patients\u2019 tumor genomes to personalize cancer therapy, one very important step may be missing, suggest Johns Hopkins researchers: a point of comparison to patients\u2019 noncancerous genomes. Without these comparisons \u2014 or a full picture of a patient\u2019s genome \u2014 nearly half of all patients may be getting the wrong cancer […]<\/p>\n","protected":false},"author":6,"featured_media":3996,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-3995","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",95,63,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",500,334,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",96,64,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/04\/shutterstock_218141077_0.jpg",150,100,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/3995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=3995"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/3995\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/3996"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=3995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=3995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=3995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}