{"id":4912,"date":"2015-06-25T06:00:41","date_gmt":"2015-06-25T06:00:41","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=4912"},"modified":"2015-06-25T06:00:41","modified_gmt":"2015-06-25T06:00:41","slug":"research-sheds-light-on-how-neurons-control-muscle-movement","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/research-sheds-light-on-how-neurons-control-muscle-movement\/","title":{"rendered":"Research Sheds Light on How Neurons Control Muscle Movement"},"content":{"rendered":"

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\"Studying<\/a>
Studying the brain activity of two patients with Lou Gehrig’s disease has given researchers insight into how neurons control muscle movement. (Image: Oliver Burston)<\/figcaption><\/figure>\n

Stanford University researchers studying how the brain controls movement in people with paralysis, related to their diagnosis of Lou Gehrig\u2019s disease, have found that groups of neurons work together, firing in complex rhythms to signal muscles about when and where to move.<\/span>

\u201cWe hope to apply these findings to create prosthetic devices, such as robotic arms, that better understand and respond to a person\u2019s thoughts,\u201d said Jaimie Henderson, M.D., professor of neurosurgery.<\/span>

A paper describing the study was published online June 23 in\u00a0eLife<\/em>. Henderson, who holds the John and Jene Blume-Robert and Ruth Halperin Professorship, and Krishna Shenoy, Ph.D., professor of electrical engineering and a Howard Hughes Medical Institute investigator, share senior authorship of the paper. The lead author is postdoctoral scholar Chethan Pandarinath, Ph.D..<\/span>

The study builds on groundbreaking Stanford animal research that fundamentally has changed how scientists think about how motor cortical neurons work to control movements. \u201cThe earlier research with animals showed that many of the firing patterns that seem so confusing when we look at individual neurons become clear when we look at large groups of neurons together as a dynamical system,\u201d Pandarinath said.<\/span>

Previously, researchers had two theories about how neurons in the motor cortex might control movement: One was that these neurons fired in patterns that represent more abstract commands, such as \u201cmove your arm to the right,\u201d and then neurons in different brain areas would translate those instructions to guide the muscle contractions that make the arm move; the other was that the motor cortex neurons would actually send directions to the arm muscles, telling them how to contract.<\/span>

But in a 2012\u00a0Nature<\/em>\u00a0paper, Shenoy and his colleagues reported finding that much more is going on: Motor cortical neurons work as part of an interconnected circuit\u00a0 \u2014 a so-called dynamical system \u2014 to create rhythmic patterns of neural activity. As these rhythmic patterns are sent to the arm, they drive muscle contractions, causing the arm to move.<\/span>

\u201cWhat we discovered in our preclinical work is evidence of how groups of neurons coordinate and cooperate with each other in a very particular way that gives us deeper insight into how the brain is controlling the arm,\u201d Shenoy said.<\/span>

He and his colleagues wanted to know whether neurons fired similarly in humans.<\/span>

Recording human brain activity<\/span>

To conduct the study, the researchers recorded motor cortical brain activity of two research participants with the degenerative neurological condition called amyotrophic lateral sclerosis, or ALS. The condition, which also is known as Lou Gehrig\u2019s disease, damages neurons and causes patients to lose control over their muscles.<\/span>

The participants, a 51-year-old woman who retained some movement in her fingers and wrists, and a 54-year-old man who could still move one of his index fingers slightly, are participants in the BrainGate2 trial, which is testing a neural interface system allowing thoughts to control computer cursors, robotic arms and other assistive devices.<\/span>

These participants had electrode arrays implanted in their brains\u2019 motor cortex for the trial. That allowed researchers to record electrical brain activity from individual neurons while the participants moved or tried to move their fingers and wrists, which were equipped with sensors to record physical movement. Typically, such mapping in humans can only occur during brain surgery.<\/span>

The participants\u2019 implants provided an \u201copportunity to ask important scientific questions,\u201d Shenoy said. The researchers found that the ALS patients\u2019 neurons worked very similarly to the preclinical research findings.<\/span>

Researchers now plan to use their data to improve the algorithms that translate neural activity in the form of electrical impulses into control signals that can guide a robotic arm or a computer cursor.<\/span>


The study was funded by the Stanford Institute for Neuro-Innovation and Translational Neuroscience, Stanford BioX\/NeuroVentures, the Stanford Office of Postdoctoral Affairs, the Garlick Foundation, the Reeve Foundation, the Craig H. Neilsen Foundation, the National Institutes of Health, the Department of Veterans Affairs and the MGH-Deane Institute for Integrated Research on Atrial Fibrillation and Stroke.<\/span>

Source: Stanford University<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Stanford University researchers studying how the brain controls movement in people with paralysis, related to their diagnosis of Lou Gehrig\u2019s disease, have found that groups of neurons work together, firing in complex rhythms to signal muscles about when and where to move.\u201cWe hope to apply these findings to create prosthetic devices, such as robotic arms, […]<\/p>\n","protected":false},"author":6,"featured_media":4913,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-4912","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",620,496,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons-300x240.jpg",300,240,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",620,496,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",620,496,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",620,496,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",620,496,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",620,496,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",620,496,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",600,480,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",600,480,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",613,490,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",450,360,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",81,65,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",620,496,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",96,77,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/06\/bt1506_stanford_neurons.jpg",150,120,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/4912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=4912"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/4912\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/4913"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=4912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=4912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=4912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}