{"id":5282,"date":"2015-07-17T06:34:44","date_gmt":"2015-07-17T06:34:44","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=5282"},"modified":"2015-07-17T06:34:44","modified_gmt":"2015-07-17T06:34:44","slug":"device-offers-remote-controlled-drug-delivery","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/device-offers-remote-controlled-drug-delivery\/","title":{"rendered":"Device Offers Remote-Controlled Drug Delivery"},"content":{"rendered":"

\"shutterstock_160124180\"<\/a>A wireless device, demonstrated for the first time in mice, can be implanted in the brain and activated by the remote push of a button to deliver drugs, according to a\u00a0study<\/span><\/a>\u00a0published today in the journal\u00a0Cell<\/em>.<\/span><\/p>\n

The technology, developed by researchers at Washington University School of Medicine in St. Louis and the University of Illinois at Urbana-Champaign, builds upon previous work in which targeted brain cells are activated with flashes of light.<\/span><\/p>\n

The\u00a0implanted device, the width of a human hair, could one day help treat pain, depression, epilepsy and other neurological disorders in people by targeting therapies to specific brain circuits, say researchers.<\/span><\/p>\n

\u201cThis approach potentially could deliver therapies that are much more targeted but have fewer side effects,\u201d said co-principal investigator Michael R. Bruchas, Ph.D., associate professor of anesthesiology and neurobiology at Washington University in a release. Currently, many medications have side effects because when administered, the drug interacts with other parts of the body that are not the intended target of the drug.<\/span><\/p>\n

By delivering a drug to a side of the mouse\u2019s brain, researchers stimulated neurons involved in movement, which caused the animal\u00a0to circle.<\/span><\/p>\n

\u201cThe device embeds microfluid channels and microscale pumps, but is soft like brain tissue and can remain in the brain and function for a long time without causing inflammation or neural damage,\u201d said co-first author Jae-Woong Jeong, Ph.D, a former postdoctoral researcher at the University of Illinois, in the release.<\/span><\/p>\n

In other mice, researchers shone a light directly onto their brain cells, which expressed a light-sensitive protein, prompting dopamine release. Researchers then halted the neurotransmitter\u2019s release with the remote-controlled release of a drug that blocks dopamine\u2019s action on receptors.<\/span><\/p>\n

Although preliminary, the research has implications for furthering the field of\u00a0drug delivery<\/span><\/a>systems.<\/span><\/p>\n

In June,\u00a0a team of researchers at Purdue University<\/span><\/a>\u00a0in Indiana created a new implantable drug-delivery system using nanowires that can be wirelessly controlled to release a preloaded drug. The system was tested in mice with compression injuries to their spinal cords and administered the corticosteroid dexamethasone.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

A wireless device, demonstrated for the first time in mice, can be implanted in the brain and activated by the remote push of a button to deliver drugs, according to a\u00a0study\u00a0published today in the journal\u00a0Cell. The technology, developed by researchers at Washington University School of Medicine in St. Louis and the University of Illinois at […]<\/p>\n","protected":false},"author":6,"featured_media":5283,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-5282","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",500,500,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180-300x300.jpg",300,300,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",500,500,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",500,500,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",500,500,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",500,500,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",500,500,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",500,500,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",500,500,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",500,500,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",490,490,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",360,360,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",65,65,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",500,500,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",96,96,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/shutterstock_160124180.jpg",150,150,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/5282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=5282"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/5282\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/5283"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=5282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=5282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=5282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}