{"id":5320,"date":"2015-07-21T09:32:53","date_gmt":"2015-07-21T09:32:53","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=5320"},"modified":"2015-07-21T09:32:53","modified_gmt":"2015-07-21T09:32:53","slug":"device-offers-remote-controlled-drug-delivery-2","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/device-offers-remote-controlled-drug-delivery-2\/","title":{"rendered":"Device Offers Remote-Controlled Drug Delivery"},"content":{"rendered":"
\"Source:<\/a>
Source: Shutterstock<\/figcaption><\/figure>\n

A wireless device, demonstrated for the first time in mice, can be implanted in the brain and activated by the remote push of a button to deliver drugs, according to a study\u00a0published\u00a0in the journal\u00a0Cell.<\/em><\/span><\/p>\n

The technology, developed by researchers at Washington University School of Medicine in St. Louis and the University of Illinois at Urbana-Champaign, builds upon previous work in which targeted brain cells are activated with flashes of light.<\/span><\/p>\n

The implanted device, the width of a human hair, could one day help treat pain, depression, epilepsy and other neurological disorders in people by targeting therapies to specific brain circuits, say researchers.<\/span><\/p>\n

\u201cThis approach potentially could deliver therapies that are much more targeted but have fewer side effects,\u201d said co-principal investigator Michael R. Bruchas, Ph.D., associate professor of anesthesiology and neurobiology at Washington University in a release. Currently, many medications have side effects because when administered, the drug interacts with other parts of the body that are not the intended target of the drug.<\/span><\/p>\n

By delivering a drug to a side of the mouse\u2019s brain, researchers stimulated neurons involved in movement, which caused the animal to circle.<\/span><\/p>\n

\u201cThe device embeds microfluid channels and microscale pumps, but is soft like brain tissue and can remain in the brain and function for a long time without causing inflammation or neural damage,\u201d said co-first author Jae-Woong Jeong, Ph.D, a former postdoctoral researcher at the University of Illinois, in the release.<\/span><\/p>\n

In other mice, researchers shone a light directly onto their brain cells, which expressed a light-sensitive protein, prompting dopamine release. Researchers then halted the neurotransmitter\u2019s release with the remote-controlled release of a drug that blocks dopamine\u2019s action on receptors.<\/span><\/p>\n

Although preliminary, the research has implications for furthering the field of drug delivery system.<\/span><\/p>\n

In June, a team of researcher at Purdue University\u00a0in Indiana created a new implantable drug-delivery system using nanowires that can be wirelessly controlled to release a preloaded drug. The system was tested in mice with compression injuries to their spinal cords and administered the corticosteroid dexamethasone.<\/span><\/p>\n

\n

Source: biosciencetechnology<\/p>\n","protected":false},"excerpt":{"rendered":"

A wireless device, demonstrated for the first time in mice, can be implanted in the brain and activated by the remote push of a button to deliver drugs, according to a study\u00a0published\u00a0in the journal\u00a0Cell. The technology, developed by researchers at Washington University School of Medicine in St. Louis and the University of Illinois at Urbana-Champaign, […]<\/p>\n","protected":false},"author":6,"featured_media":5321,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,17],"tags":[],"class_list":["post-5320","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovation","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",500,500,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro-300x300.jpg",300,300,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",500,500,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",500,500,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",500,500,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",500,500,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",500,500,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",500,500,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",500,500,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",500,500,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",490,490,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",360,360,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",65,65,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",500,500,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",96,96,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/07\/bt1507_neuro.jpg",150,150,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Innovation<\/a> Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/5320","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=5320"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/5320\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/5321"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=5320"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=5320"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=5320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}