{"id":5873,"date":"2015-08-23T16:56:43","date_gmt":"2015-08-23T16:56:43","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=5873"},"modified":"2015-08-23T16:56:43","modified_gmt":"2015-08-23T16:56:43","slug":"researchers-discover-ancient-origins-of-deadly-lassa-virus","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/researchers-discover-ancient-origins-of-deadly-lassa-virus\/","title":{"rendered":"Researchers Discover Ancient Origins of Deadly Lassa Virus"},"content":{"rendered":"
\"Kristian<\/a>
Kristian G. Andersen is a biologist at The Scripps Research Institute. Source: TSRI<\/figcaption><\/figure>\n

Working as part of an international team in North America and West Africa, a researcher at The Scripps Research Institute (TSRI) has published new findings showing the ancient roots of the deadly Lassa virus, a relative of Ebola virus, and how Lassa virus has changed over time.<\/span><\/p>\n

\u201cThis gives us a clear view of how the virus is evolving, which is important to know as we develop vaccines and therapies,\u201d said TSRI biologist Kristian G. Andersen, a lead author of the new study.<\/span><\/p>\n

At least 5,000 people die each year from Lassa fever. The virus is spread through contact with urine and droppings from infected Mastomys natalensis rodents (which are a natural \u201creservoir\u201d of the virus)\u2014and the disease can spread from human to human.<\/span><\/p>\n

In the new study, published August 13 in the journal Cell, the team\u2014whose senior members included Pardis Sabeti and Joshua Levin of Harvard University and the Broad Institute, Robert F. Garry of Tulane University and Christian Happi of Nigeria\u2019s Irrua Specialist Teaching Hospital and Sierra Leone\u2019s Kenema Government Hospital\u2014used a technique called next-generation sequencing to analyze genomes of Lassa virus samples taken from wild Mastomys natalensis and human patients in Nigeria and Sierra Leone.<\/span><\/p>\n

[pullquote]The genomic data showed that far-flung strains of Lassa virus share a common ancestor that can be traced back more than 1,000 years to an area today known as Nigeria.[\/pullquote]\u00a0This surprised the researchers, as Lassa fever was first described in Nigeria in 1969. \u201cThe virus has very ancient roots,\u201d said Andersen.<\/span><\/p>\n

The researchers found that the virus spread out of Nigeria about 400 years ago and over the past couple of hundred years moved into Guinea, Liberia and Sierra Leone\u2014the same part of the world where the largest outbreak of Ebola virus has been raging since 2013. As Lassa virus spread, the virus mutated and seemed to better adapt to mammalian hosts.<\/span><\/p>\n

The new data also show that most Lassa fever cases are caused by frequent \u201cspillover\u201d infections from the wild rodent reservoir to humans, rather than spreading from human to human. \u201cThe reason Lassa hasn\u2019t yet grown into this huge epidemic is because there is limited transmission between humans,\u201d said Andersen. \u201cThat\u2019s a major difference between Lassa virus and Ebola virus.\u201d<\/span><\/p>\n

Andersen noted that local scientists in West Africa were key for this new study and will be crucial for future studies in the region. He views the next step in this research as understanding how the virus mutates within individual hosts as it confronts the immune system.<\/span><\/p>\n

Source:\u00a0TSRI<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Working as part of an international team in North America and West Africa, a researcher at The Scripps Research Institute (TSRI) has published new findings showing the ancient roots of the deadly Lassa virus, a relative of Ebola virus, and how Lassa virus has changed over time. \u201cThis gives us a clear view of how […]<\/p>\n","protected":false},"author":2,"featured_media":5874,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-5873","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",1000,1437,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian-208x300.jpg",208,300,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",750,1078,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian-712x1024.jpg",712,1024,true],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",1000,1437,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",1000,1437,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",557,800,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",397,570,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",600,862,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",418,600,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",341,490,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",251,360,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",45,65,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",594,853,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",67,96,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/08\/ddd1508_andersen_kristian.jpg",150,216,false]},"author_info":{"info":["RevoScience"]},"category_info":"Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/5873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=5873"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/5873\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/5874"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=5873"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=5873"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=5873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}