{"id":6056,"date":"2015-09-02T09:35:38","date_gmt":"2015-09-02T09:35:38","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=6056"},"modified":"2015-09-02T09:35:38","modified_gmt":"2015-09-02T09:35:38","slug":"genetic-clues-associated-with-cigarette-addiction","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/genetic-clues-associated-with-cigarette-addiction\/","title":{"rendered":"Genetic Clues Associated with Cigarette Addiction"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"color: #000000;\"><a href=\"http:\/\/revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-6057\" src=\"http:\/\/revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke-300x199.jpg\" alt=\"ddd1509_smoke\" width=\"300\" height=\"199\" title=\"\" srcset=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke-300x199.jpg 300w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg 620w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Researchers at the Virginia Commonwealth University School of Pharmacy have identified specific sets of genetic variants that are significantly associated with cigarette addiction. Pinpointing these genetic variants could eventually assist in identifying the biological mechanism behind nicotine addiction and in generating novel drug therapy targets to help people break their addiction to nicotine.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">The study, \u201cDeep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses,\u201d was published in August as an advanced online publication in the Oxford University Press journal Nicotine &amp; Tobacco Research.<\/span><\/p>\n<p style=\"text-align: justify;\">[pullquote]Researchers at the CBRPM sequenced the three genes and their adjacent regions to get a complete catalog of all the genetic variation that could be contributing to addiction.[\/pullquote]<\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">\u201cWe dug deeper into genes known to be associated with smoking,\u201d said Shaunna L. Clark, Ph.D., research assistant professor, Center for Biomarker Research and Precision Medicine, VCU School of Pharmacy. Previous large-scale, genomewide association studies have identified three genes that are related to cigarette addiction, but the VCU-led study is the first to identify specific sets of genetic variants that might be responsible.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Researchers at the CBRPM sequenced the three genes and their adjacent regions to get a complete catalog of all the genetic variation that could be contributing to addiction. Sequencing the entire gene allowed Clark and her colleagues to examine variants that other studies had not addressed, such as rare variants not commonly found in the population and regulatory variants that can increase or decrease gene expression.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">\u201cWe found that the tendency toward nicotine addiction is likely caused by many variants, each with a small effect,\u201d Clark said. \u201cThus, multiple variants within the same gene are related to smoking.\u201d<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Source: <span style=\"color: #808080;\"><a href=\"http:\/\/news.vcu.edu\/article\/VCU_researchers_identify_genetic_clues_associated_with_cigarette?\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #808080;\">VCU<\/span><\/a><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the Virginia Commonwealth University School of Pharmacy have identified specific sets of genetic variants that are significantly associated with cigarette addiction. <\/p>\n","protected":false},"author":6,"featured_media":6057,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-6056","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",620,413,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke-300x199.jpg",300,199,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",620,413,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",620,413,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",620,413,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",620,413,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",620,413,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",620,413,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",600,400,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",600,400,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",620,413,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",540,360,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",95,63,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",620,413,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",96,64,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2015\/09\/ddd1509_smoke.jpg",150,100,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"<a href=\"https:\/\/www.revoscience.com\/en\/category\/news\/research\/\" rel=\"category tag\">Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/6056","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=6056"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/6056\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/6057"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=6056"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=6056"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=6056"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}