{"id":8351,"date":"2016-04-08T06:35:53","date_gmt":"2016-04-08T06:35:53","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=8351"},"modified":"2016-04-08T06:35:53","modified_gmt":"2016-04-08T06:35:53","slug":"engineers-develop-a-pill-for-long-term-drug-release","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/engineers-develop-a-pill-for-long-term-drug-release\/","title":{"rendered":"Engineers develop a pill for long-term drug release"},"content":{"rendered":"

New tablet attaches to the lining of the GI tract, resists being pulled away.<\/em><\/strong><\/span><\/p>\n

\"Researchers<\/a>
Researchers have created a new type of dual-sided pill that attaches to the gastrointestinal tract. One side of the pill sticks to mucosal surfaces, while the other is omniphobic, meaning that it repels everything it encounters.
Illustration: Christine Daniloff\/MIT<\/figcaption><\/figure>\n

CAMBRIDGE, MA<\/strong> — Researchers from MIT and Brigham and Women\u2019s Hospital have designed a new type of pill that, once swallowed, can attach to the lining of the gastrointestinal tract and slowly release its contents. The tablet is engineered so that one side adheres to tissue, while the other repels food and liquids that would otherwise pull it away from the attachment site.<\/span>
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Such extended-release pills could be used to reduce the dosage frequency of some drugs, the researchers say. For example, antibiotics that normally have to be taken two or three times a day could be given just once, making it easier for patients to stick to their dosing schedule.<\/span>
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\u201cThis could be adapted to many drugs. Any drug that is dosed frequently could be amenable to this kind of system,\u201d says Giovanni Traverso, a research affiliate at MIT\u2019s Koch Institute for Integrative Cancer Research, a gastroenterologist at Brigham and Women\u2019s Hospital, and one of the senior authors of a paper describing the device in the April 6 issue of the journal\u00a0<\/span>Advanced Healthcare Materials<\/em>.<\/span><\/span>
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Robert Langer, the David H. Koch Institute Professor and a member of the Koch Institute, is also a senior author of the paper. The paper\u2019s lead author is Young-Ah Lucy Lee, a technical assistant at the Koch Institute.<\/span>
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Two faces<\/strong><\/span>
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Over the past several decades, Langer\u2019s lab has developed many types of materials that can be implanted in the body or attached to the skin for long-term drug release. To achieve similar, long-term drug release in the gastrointestinal tract, the researchers focused on a type of material known as mucoadhesives, which can stick to the mucosal linings of organs such as the stomach.<\/span>
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[pullquote]To achieve similar, long-term drug release in the gastrointestinal tract, the researchers focused on a type of material known as mucoadhesives, which can stick to the mucosal linings of organs such as the stomach.[\/pullquote]<\/p>\n

Scientists have previously explored using this kind of material for drug delivery to the GI tract, but it has proven difficult because food and liquid in the stomach become stuck to the tablet, pulling it away from the tissue before it can deliver its entire drug payload.<\/span>
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\u201cThe challenge with mucoadhesives is that the GI tract is a very rough and abrasive environment,\u201d says Lee, a 2014 Wellesley College graduate who began this project as her senior thesis.<\/span>
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To overcome this challenge, the researchers decided to create a dual-sided device, also called a Janus device after the two-faced Roman god. One side sticks to mucosal surfaces, while the other is omniphobic, meaning that it repels everything it encounters.<\/span>
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For the mucoadhesive side, the researchers used a commercially available polymer known as Carbopol, which is often used industrially as a stabilizing or thickening agent. The omniphobic side consists of cellulose acetate that the researchers textured so that its surface would mimic that of a lotus leaf, which has micro and nanoscale protrusions that make it extremely hydrophobic. They then fluorinated and lubricated the surface, making it repel nearly any material.<\/span>
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The researchers used a pill presser to combine the polymers into two-sided tablets, which can be formed in many shape and sizes. Drugs can be either embedded within the cellulose acetate layer or placed between the two layers.<\/span>
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Long-term attachment<\/strong><\/span>
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Using intestinal tissue from pigs, the researchers tested three versions of the tablet \u2014 a dual-sided mucoadhesive tablet, a dual-sided omniphobic tablet, and the Janus version, with one mucoadhesive side and one omniphobic side.<\/span>
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To simulate the tumultuous environment of the GI tract, the researchers flowed a mix of food including liquids and small pieces of bread and rice along the tissue and then added the tablets. The dual-sided omniphobic tablet took less than 1 second to travel along the tissue, and the dual-sided mucoadhesive stuck to the tissue for only 7 seconds before being pulled off. The Janus version stayed attached for the length of the experiment, about 10 minutes.<\/span>
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The researchers now plan to do further tests in animals to help them tune how long the tablets can stay attached, the rate at which drugs are released from the material, and the ability to target the material to specific sections of the GI tract.<\/span>
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In addition to delivering antibiotics, the two-sided material may help to simplify drug regimens for malaria or tuberculosis, among other diseases, Traverso says. The researchers may also further pursue the development of tablets with omniphobic coatings on both sides, which they believe could help patients who have trouble swallowing pills.<\/span>
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\u201cThere are certain medications that are known to get stuck, particularly in the esophagus. It causes this massive amount of inflammation because it gets stuck and it causes irritation,\u201d Traverso says. \u201cTexturing the surfaces really opens up a new way of thinking about controlling and tuning how these drug formulations travel.\u201d<\/span>
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The research was funded by the Bill and Melinda Gates Foundation, the National Institutes of Health, and the Alexander von Humboldt Foundation.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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