{"id":8387,"date":"2016-04-10T09:05:13","date_gmt":"2016-04-10T09:05:13","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=8387"},"modified":"2016-04-10T09:46:29","modified_gmt":"2016-04-10T09:46:29","slug":"marijuana-receptor-might-hold-the-key-to-new-fertility-treatments-for-men","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/marijuana-receptor-might-hold-the-key-to-new-fertility-treatments-for-men\/","title":{"rendered":"&#8216;Marijuana receptor&#8217; might hold the key to new fertility treatments for men"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"color: #000000;\"><em><strong>Research suggests that cannabis exposure may affect DNA-bound proteins, sperm chromatin and have an impact on fertility, embryo development and offspring health<\/strong><\/em><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\"><a href=\"http:\/\/revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-8399\" src=\"http:\/\/revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360-300x200.jpg\" alt=\"160408163828_1_540x360\" width=\"300\" height=\"200\" title=\"\" srcset=\"https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360-300x200.jpg 300w, https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg 540w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>In a research report appearing in the April 2016 issue of\u00a0<em>The FASEB Journal<\/em>, scientists show that a cannabinoid receptor, called &#8220;CB2,&#8221; helps regulate the creation of sperm. Not only does this provide more evidence that marijuana can disrupt fertility in males, but it also suggests a therapeutic strategy for treating male infertility.<\/span><\/p>\n<p id=\"text\" style=\"font-weight: normal; text-align: justify;\"><span style=\"color: #000000;\">&#8220;The possibility to improve male fertility is one of the main focuses of this study, since infertility is a worldwide problem that affect up to 15% of couples in which male factors account for almost 20-70%,&#8221; said Paola Grimaldi, Ph.D., a researcher involved in the work from the Department of Biomedicine and Prevention, School of Medicine at the University of Rome Tor Vergata in Rome, Italy.<\/span><\/p>\n<p style=\"font-weight: normal; text-align: justify;\"><span style=\"color: #000000;\">To make their discovery, Grimaldi and colleagues treated three groups of mice with different agents for 14 to 21 days. The first group was treated with a specific activator of the CB2 receptor. The second group was treated with a specific inhibitor of the CB2 receptor. The third group received only a saline solution and served as the control group. The group treated with the CB2 activator showed an acceleration of spermatogenesis, while the group treated with the inhibitor displayed a slower rate of the process. This suggests that a tight balance of CB2 activation is required for the proper progression of spermatogenesis.<\/span><\/p>\n<p style=\"font-weight: normal; text-align: justify;\"><span style=\"color: #000000;\">&#8220;That the normal beneficial effects of endogenous cannabinoids on spermatogenesis can be stimulated further by a chemical mimic, an agonist, is a potentially promising new idea for treating male infertility,&#8221; said Thoru Pederson, Ph.D., Editor-in-Chief of\u00a0<em>The FASEB Journal<\/em>.<\/span><\/p>\n<p style=\"font-weight: normal; text-align: justify;\"><span style=\"color: #000000;\">Source: <a href=\"https:\/\/www.sciencedaily.com\/releases\/2016\/04\/160408163828.htm?utm_source=dlvr.it&amp;utm_medium=facebook\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #000000;\">Sciencedaily<\/span><\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research suggests that cannabis exposure may affect DNA-bound proteins, sperm chromatin and have an impact on fertility, embryo development and offspring health.<\/p>\n","protected":false},"author":6,"featured_media":8399,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-8387","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360-300x200.jpg",300,200,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",95,63,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",540,360,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",96,64,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/04\/160408163828_1_540x360.jpg",150,100,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"<a href=\"https:\/\/www.revoscience.com\/en\/category\/news\/research\/\" rel=\"category tag\">Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/8387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=8387"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/8387\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/8399"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=8387"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=8387"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=8387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}