{"id":9821,"date":"2016-08-31T09:01:43","date_gmt":"2016-08-31T09:01:43","guid":{"rendered":"http:\/\/revoscience.com\/en\/?p=9821"},"modified":"2016-08-31T09:01:43","modified_gmt":"2016-08-31T09:01:43","slug":"researchers-develop-reversible-blood-thinner","status":"publish","type":"post","link":"https:\/\/www.revoscience.com\/en\/researchers-develop-reversible-blood-thinner\/","title":{"rendered":"Researchers Develop \u2018Reversible\u2019 Blood Thinner"},"content":{"rendered":"
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\"Researchers<\/a>
Researchers have developed an antibody that prevents blood clots without causing bleeding, a risk associated with current anticoagulant drugs. (Credit: Chris Bickel \/ Science Translational Medicine (2016) )<\/figcaption><\/figure>\n

Blood clots can be dangerous and cause heart attacks or strokes, but current blood thinners often come with the risk of uncontrolled bleeding.\u00a0 In a new paper, published Aug. 24 in\u00a0<\/span>Science Translational Medicine<\/em><\/a>, scientists report on a new antibody that prevents blood clots from forming without the risk of spontaneous bleeding.\u00a0 Researchers also describe a second antibody that works as an antidote that can quickly reverse the effects.<\/span><\/p>\n

The antibody specifically binds to coagulation factor Xla (FXla), which is a protein that has a vital role in the formation of blood clots.\u00a0 While this protein is seen as a major drug target, it has been difficult to specifically inhibit FXla.\u00a0 The new antibody does so, and blocks enzymatic activity.\u00a0<\/span><\/p>\n

For the new study, researchers, led by Tovo David showed that the drug was successful in preventing blood clots in blood of mice, rabbits and humans.<\/span><\/p>\n

Safety was assessed in monkey\u2019s, who showed no signs of bleeding even when the drug was administered at doses much higher than needed to prevent clotting.<\/span><\/p>\n

The authors believe that with further progress the FXla-specific antibody, the effects of which are reversible, could offer a new and potentially safer class of blood thinners.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

The antibody specifically binds to coagulation factor Xla (FXla), which is a protein that has a vital role in the formation of blood clots. While this protein is seen as a major drug target, it has been difficult to specifically inhibit FXla. The new antibody does so, and blocks enzymatic activity. <\/p>\n

For the new study, researchers, led by Tovo David showed that the drug was successful in preventing blood clots in blood of mice, rabbits and humans.<\/p>\n","protected":false},"author":6,"featured_media":9822,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26,17],"tags":[],"class_list":["post-9821","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine","category-research"],"featured_image_urls":{"full":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",800,600,false],"thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner-150x150.jpg",150,150,true],"medium":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner-300x225.jpg",300,225,true],"medium_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",750,563,false],"large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",750,563,false],"1536x1536":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",800,600,false],"2048x2048":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",800,600,false],"ultp_layout_landscape_large":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",800,600,false],"ultp_layout_landscape":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",760,570,false],"ultp_layout_portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",600,450,false],"ultp_layout_square":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",600,450,false],"newspaper-x-single-post":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",653,490,false],"newspaper-x-recent-post-big":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",480,360,false],"newspaper-x-recent-post-list-image":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",87,65,false],"web-stories-poster-portrait":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",640,480,false],"web-stories-publisher-logo":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",96,72,false],"web-stories-thumbnail":["https:\/\/www.revoscience.com\/en\/wp-content\/uploads\/2016\/08\/bt1608_bloodthinner.jpg",150,113,false]},"author_info":{"info":["Amrita Tuladhar"]},"category_info":"Medicine<\/a> Research<\/a>","tag_info":"Research","comment_count":"0","_links":{"self":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/9821","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/comments?post=9821"}],"version-history":[{"count":0,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/posts\/9821\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media\/9822"}],"wp:attachment":[{"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/media?parent=9821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/categories?post=9821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.revoscience.com\/en\/wp-json\/wp\/v2\/tags?post=9821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}